Quantitative assessment of early diabetic retinopathy using fractal analysis.
Quantitative assessment of early diabetic retinopathy using fractal analysis.
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DOI：
10.2337/dc08-1233
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发表时间：
2009-01
期刊：
影响因子：
16.2
通讯作者：
Wong, Tien Y.
中科院分区：
文献类型：
--
作者：
Cheung, Ning;Donaghue, Kim C.;Liew, Gerald;Rogers, Sophie L.;Wang, Jie Jin;Lim, Shueh-Wen;Jenkins, Alicia J.;Hsu, Wynne;Lee, Mong Li;Wong, Tien Y.
分形分析可以量化视网膜血管分支模式的几何复杂性，因此可能提供一种新的方法来量化早期糖尿病微血管损伤。在这项研究中，我们研究了视网膜分形维数与1型糖尿病患者视网膜病变之间的关系。研究设计和方法-我们对729名1型糖尿病患者（年龄12-20岁）进行了一项横断面研究，这些患者的双眼都进行了7视野立体视网膜摄影。根据这些照片，视网膜病变根据改良的Airlie House分类进行分级，并使用基于计算机的程序按照标准化方案量化分形维数。在这项研究中，137例患者（18.8%）有糖尿病视网膜病变体征;其中105例有轻度视网膜病变。视网膜分形维数中位数（四分位距）为1.46214（1.45023-1.47217）。校正年龄、性别、糖尿病病程、A1 C、血压和总胆固醇后，视网膜血管分形维数的增加与视网膜病变几率的增加显著相关（分形维数第四与第一四分位数的比值比为3.92 [95%CI 2.02-7.61]）。在多变量分析中，视网膜血管分形维数每增加0.01与视网膜病变几率增加近40%相关（1.37 [1.21-1.56]）。在对视网膜血管口径进行额外调整后，这种相关性仍然存在。结论：视网膜分形维数越大，代表视网膜血管几何复杂性增加，与1型糖尿病早期糖尿病视网膜病变体征独立相关。眼底照片的分形分析可以定量测量早期糖尿病微血管损伤。
OBJECTIVE—Fractal analysis can quantify the geometric complexity of the retinal vascular branching pattern and may therefore offer a new method to quantify early diabetic microvascular damage. In this study, we examined the relationship between retinal fractal dimension and retinopathy in young individuals with type 1 diabetes. RESEARCH DESIGN AND METHODS—We conducted a cross-sectional study of 729 patients with type 1 diabetes (aged 12–20 years) who had seven-field stereoscopic retinal photographs taken of both eyes. From these photographs, retinopathy was graded according to the modified Airlie House classification, and fractal dimension was quantified using a computer-based program following a standardized protocol. RESULTS—In this study, 137 patients (18.8%) had diabetic retinopathy signs; of these, 105 had mild retinopathy. Median (interquartile range) retinal fractal dimension was 1.46214 (1.45023–1.47217). After adjustment for age, sex, diabetes duration, A1C, blood pressure, and total cholesterol, increasing retinal vascular fractal dimension was significantly associated with increasing odds of retinopathy (odds ratio 3.92 [95% CI 2.02–7.61] for fourth versus first quartile of fractal dimension). In multivariate analysis, each 0.01 increase in retinal vascular fractal dimension was associated with a nearly 40% increased odds of retinopathy (1.37 [1.21–1.56]). This association remained after additional adjustment for retinal vascular caliber. CONCLUSIONS—Greater retinal fractal dimension, representing increased geometric complexity of the retinal vasculature, is independently associated with early diabetic retinopathy signs in type 1 diabetes. Fractal analysis of fundus photographs may allow quantitative measurement of early diabetic microvascular damage.
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影响因子：
2
作者：
DAXER, A
通讯作者：
DAXER, A
影响因子：
16.2
作者：
Nguyen, Thanh Tan;Wang, Jie Jin;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
16.2
作者：
Cheung, Ning;Rogers, Sophie L.;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
3.9
作者：
MAINSTER, MA
通讯作者：
MAINSTER, MA
影响因子：
10.6
作者：
Stosic, Tatijana;Stosic, Borko D.
通讯作者：
Stosic, Borko D.