The serum vaspin levels are reduced in Japanese chronic hemodialysis patients.
The serum vaspin levels are reduced in Japanese chronic hemodialysis patients.
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DOI：
10.1186/1471-2369-13-163
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发表时间：
2012-12-03
期刊：
影响因子：
2.3
通讯作者：
Makino H
中科院分区：
文献类型：
--
作者：
Inoue J;Wada J;Teshigawara S;Hida K;Nakatsuka A;Takatori Y;Kojo S;Akagi S;Nakao K;Miyatake N;McDonald JF;Makino H
内脏脂肪组织衍生丝氨酸蛋白酶抑制剂（vaspin）是一种在遗传肥胖大鼠中发现的脂肪因子，与人类胰岛素抵抗和肥胖相关。最近，我们发现7%的具有rs77060950小等位基因序列(A)的日本人血清血管素水平较高。因此，我们评估了日本慢性血液透析患者的血清vaspin水平。本研究招募了健康的日本对照志愿者（对照组，n = 95, 49.9±6.91年）和接受血液透析治疗的日本患者（HD患者，n = 138, 51.4±10.5年），并将血清样本进行人血管素RIA系统检测。血清vaspin水平的测量表明，一小部分对照组（n = 5）和HD患者（n = 11）的vaspin水平高得多（10 ng/ml； VaspinHigh组），而其余人群的VaspinLow组的vaspin水平较低（< 3 ng/ml； VaspinLow组）。对照VaspinLow组患者血清vaspin水平（0.87±0.24 ng/ml）明显高于HD组（0.32±0.15 ng/ml） （p < 0.0001）。在逐步回归分析中，发现血清肌酐和甘油三酯水平与所有受试者的vaspin浓度独立且显著相关。肌酸酐水平与血清vaspin水平呈负相关，在VaspinLow组的日本HD患者中显著降低。
Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients. Healthy Japanese control volunteers (control; n = 95, 49.9±6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4±10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system. The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; VaspinHigh group), while the rest of the population exhibited lower levels (< 3 ng/ml; VaspinLow group). By comparing the patients in the VaspinLow group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87±0.24 ng/ml) than in the HD patients (0.32±0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects. The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the VaspinLow group.
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