Mitochondrial iron transport and homeostasis in plants.

Mitochondrial iron transport and homeostasis in plants.
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DOI:
10.3389/fpls.2013.00348
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发表时间:
2013-09-06
影响因子:
5.6
通讯作者:
Connolly EL
Connolly EL
中科院分区:
生物学2区
文献类型:
--
作者:
Jain A;Connolly EL

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铁是植物必需的营养物质,虽然控制土壤中铁吸收的机制已被较好地了解,但对植物细胞中铁的亚细胞运输知之甚少。线粒体是细胞内重要的铁库,因为呼吸链蛋白复合体的正常运作需要铁。线粒体是铁-S簇合成的部位,也可能是血红素合成的部位。在这里,我们回顾了控制线粒体铁运输和动态平衡的分子机制的最新见解。我们重点介绍了最近发现的水稻线粒体铁吸收转运体,以及金属还原酶在线粒体铁吸收中的可能作用。此外,我们重点介绍了线粒体铁稳态的最新进展,重点介绍了Frataxin和Ferritin在线粒体内铁运输和存储中的作用。
Iron (Fe) is an essential nutrient for plants and although the mechanisms controlling iron uptake from the soil are relatively well understood, comparatively little is known about subcellular trafficking of iron in plant cells. Mitochondria represent a significant iron sink within cells, as iron is required for the proper functioning of respiratory chain protein complexes. Mitochondria are a site of Fe–S cluster synthesis, and possibly heme synthesis as well. Here we review recent insights into the molecular mechanisms controlling mitochondrial iron transport and homeostasis. We focus on the recent identification of a mitochondrial iron uptake transporter in rice and a possible role for metalloreductases in iron uptake by mitochondria. In addition, we highlight recent advances in mitochondrial iron homeostasis with an emphasis on the roles of frataxin and ferritin in iron trafficking and storage within mitochondria.
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