Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review.
Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review.
复制标题
DOI：
10.3390/biomedicines11020644
复制
发表时间：
2023-02-20
期刊：
影响因子：
4.7
通讯作者：
Armamento-Villareal R
中科院分区：
文献类型：
--
作者：
Deepika F;Bathina S;Armamento-Villareal R
肥胖和骨质疏松症日益加重的负担是一个主要的公共卫生问题。在过去的十年中，越来越多的证据表明脂肪因子在骨代谢中的作用导致了新的脂肪因子的发现。肥胖被认为是脂肪组织炎症的一种状态，对骨骼健康有不利影响。白色脂肪组织（WAT）和骨髓脂肪组织（BMAT）分泌的脂肪因子对成骨细胞和破骨细胞的存活和功能具有内分泌和旁分泌作用。骨髓脂肪的增加与骨质疏松有关，因此，了解脂肪细胞和骨骼之间复杂的相互作用是至关重要的。本文综述了不同脂肪因子在骨代谢中的作用的最新研究进展。方法：这是对PubMED和Cochrane数据库中可用文献的综合综述，重点是最近五年使用的关键词。结果：瘦素对骨代谢有一定的积极作用；相反，脂联素和趋化素一直显示与骨密度呈负相关。抵抗素和骨密度之间没有明显的联系。新的脂肪因子如visfatin， LCN-2, Nesfatin-1, RBP-4， apelin和vaspin已经显示出骨保护和骨合成代谢特性，可以转化为治疗靶点。结论：新的证据表明，新的脂肪因子可能作为骨质疏松症风险预测的生物标志物，并作为骨质疏松症治疗的靶点。
The growing burden of obesity and osteoporosis is a major public health concern. Emerging evidence of the role of adipokines on bone metabolism has led to the discovery of novel adipokines over the last decade. Obesity is recognized as a state of adipose tissue inflammation that adversely affects bone health. Adipokines secreted from white adipose tissue (WAT) and bone marrow adipose tissue (BMAT) exerts endocrine and paracrine effects on the survival and function of osteoblasts and osteoclasts. An increase in marrow fat is implicated in osteoporosis and, hence, it is crucial to understand the complex interplay between adipocytes and bone. The objective of this review is to summarize recent advances in our understanding of the role of different adipokines on bone metabolism. Methods: This is a comprehensive review of the literature available in PubMED and Cochrane databases, with an emphasis on the last five years using the keywords. Results: Leptin has shown some positive effects on bone metabolism; in contrast, both adiponectin and chemerin have consistently shown a negative association with BMD. No significant association was found between resistin and BMD. Novel adipokines such as visfatin, LCN-2, Nesfatin-1, RBP-4, apelin, and vaspin have shown bone-protective and osteoanabolic properties that could be translated into therapeutic targets. Conclusion: New evidence suggests the potential role of novel adipokines as biomarkers to predict osteoporosis risk, and as therapeutic targets for the treatment of osteoporosis.
登录
查看更多内容
影响因子：
3.4
作者：
Baek JM;Ahn SJ;Cheon YH;Lee MS;Oh J;Kim JY
通讯作者：
Kim JY
影响因子：
5.6
作者：
Achari AE;Jain SK
通讯作者：
Jain SK
影响因子：
4.4
作者：
Ansari, Mohammed Ghouse Ahmed;Hussain, Syed Danish;Al-Daghri, Nasser M.
通讯作者：
Al-Daghri, Nasser M.
DOI：
10.3390/ma15010333
发表时间：
2022-01-03
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Skic A;Puzio I;Tymicki G;Kołodziej P;Pawłowska-Olszewska M;Skic K;Beer-Lech K;Bieńko M;Gołacki K
通讯作者：
Gołacki K
影响因子：
6.2
作者：
Bartell, Shoshana M.;Rayalam, Srujana;Baile, Clifton A.
通讯作者：
Baile, Clifton A.