Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions.
Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions.
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DOI：
10.3390/ma15010333
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发表时间：
2022-01-03
期刊：
影响因子：
--
通讯作者：
Gołacki K
中科院分区：
文献类型：
--
作者：
Skic A;Puzio I;Tymicki G;Kołodziej P;Pawłowska-Olszewska M;Skic K;Beer-Lech K;Bieńko M;Gołacki K
骨组织在不同载荷条件下的响应研究从临床和工程的角度来看是重要的。本文分析了nesfatin-1对大鼠肱骨力学性能的影响。对三个大鼠骨组进行经典的三点弯曲和冲击测试：对照组（SHO）、在确定的骨质减少条件下的动物的肱骨（OVX）和在卵巢切除术后接受nesfatin-1的大鼠的骨（内斯）。实验证明，在各种机械负荷条件下测量的骨强度参数在给予nesfatin-1后增加。OVX骨最易变形，断裂韧性最小。该组肱骨骨折表面的SEM图像显示，与SHO和内斯雌性大鼠相比，去卵巢大鼠具有更疏松的骨结构。骨结构的松动也通过密度测定和定性EDS分析证实，显示OVX骨的矿物质含量降低。通过在准静态和冲击条件下获得的最大力的最大值对内斯组样本进行表征。SHO和内斯组在冲击过程中吸收的能量和断裂临界能量（来自三点弯曲试验）相似。在所有分析样品组的平均Fi max值之间观察到统计学显著性差异。结果表明，冲击试验比经典的准静态三点弯曲试验灵敏。因此，Fimax可作为预测骨断裂韧性的参数。
The investigations on the response of bone tissue under different loading conditions are important from clinical and engineering points of view. In this paper, the influence of nesfatin-1 administration on rat humerus mechanical properties was analyzed. The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). The experiments proved that the bone strength parameters measured under various mechanical loading conditions increased after the nesfatin-1 administration. The OVX bones were most susceptible to deformation and had the smallest fracture toughness. The SEM images of humerus fracture surface in this group showed that ovariectomized rats had a much looser bone structure compared to the SHO and NES females. Loosening of the bone structure was also confirmed by the densitometric and qualitative EDS analysis, showing a decrease in the OVX bones’ mineral content. The samples of the NES group were characterized by the largest values of maximum force obtained under both quasi-static and impact conditions. The energies absorbed during the impact and the critical energy for fracture (from the three-point bending test) were similar for the SHO and NES groups. Statistically significant differences were observed between the mean Fi max values of all analyzed sample groups. The obtained results suggest that the impact test was more sensitive than the classical quasi-static three-point bending one. Hence, Fi max could be used as a parameter to predict bone fracture toughness.
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影响因子：
2.2
作者：
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