High APLN Expression Predicts Poor Prognosis for Glioma Patients.
High APLN Expression Predicts Poor Prognosis for Glioma Patients.
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DOI：
10.1155/2022/8393336
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发表时间：
2022
影响因子：
--
通讯作者：
Guo, Xiangqian
中科院分区：
文献类型：
--
作者：
Lv, Shuangyu;An, Yang;Dong, Huan;Xie, Longxiang;Zheng, Hong;Cheng, Xiaoxia;Zhang, Lei;Teng, Tieshan;Wang, Qiang;Yan, Zhongyi;Guo, Xiangqian
Apelin（APLN）是G蛋白偶联受体APJ（APLNR）的内源性配体。APLN/APLNR系统参与肿瘤的发生、发展等多种病理生理功能。然而，其在中枢神经系统（CNS）癌症患者中的预后作用仍然未知。本研究旨在通过整合Oncomine、GEPIA、LOGpc、STRING、GeneMANIA和免疫组织化学染色的数据，探索APLN/APLNR的表达谱、预后意义和相互作用网络。结果表明，与正常CNS组织相比，APLN和APLNR mRNA表达在CNS癌症中显著增加，包括低级别胶质瘤（LGG）和胶质母细胞瘤（GBM）。APLN的高表达与LGG患者的总生存期（OS）、无复发生存期（RFS）和无进展生存期（PFS）显著相关，而APLNR的高表达与之无关。然而，APLN和APLNR表达均与GBM患者的OS、无病间期（DFI）、疾病特异性生存期（DSS）或无进展间期（PFI）方面的预后价值无显著相关。此外，免疫组织化学染色证实，与I级相比，II级LGG患者组织中APLN表达增加。这些结果表明，APLN水平升高可以预测LGG患者的OS，RFS和PFS较差，并且它可能是LGG的有希望的预后生物标志物。
Apelin (APLN) is an endogenous ligand of the G protein-coupled receptor APJ (APLNR). APLN/APLNR system was involved in a variety of pathological and physiological functions, such as tumorigenesis and development. However, its prognostic roles in patients with central nervous system (CNS) cancers remain unknown. The present study was designed to explore the expression profile, prognostic significance, and interaction network of APLN/APLNR by integrating data from Oncomine, GEPIA, LOGpc, STRING, GeneMANIA, and immunohistochemical staining. The results demonstrated that APLN and APLNR mRNA expression were significantly increased in CNS cancers, including both low-grade glioma (LGG) and glioblastoma (GBM), when compared with normal CNS tissues. The high APLN, but not APLNR, expression was significantly correlated with overall survival (OS), recurrence free survival (RFS), and progression free survival (PFS) of LGG patients. However, neither APLN nor APLNR expression was significantly related to prognostic value in terms of OS, disease free interval (DFI), disease specific survival (DSS), or progression free interval (PFI) for GBM patients. Additionally, immunohistochemistry staining confirmed the increased APLN expression in tissues of LGG patients with grade II than grade I. These results showed that an elevated APLN level could predict poor OS, RFS, and PFS for LGG patients, and it could be a promising prognostic biomarker for LGG.
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DOI：
10.1093/brain/awx253
发表时间：
2017-11-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Harford-Wright E;Andre-Gregoire G;Jacobs KA;Treps L;Le Gonidec S;Leclair HM;Gonzalez-Diest S;Roux Q;Guillonneau F;Loussouarn D;Oliver L;Vallette FM;Foufelle F;Valet P;Davenport AP;Glen RC;Bidere N;Gavard J
通讯作者：
Gavard J
影响因子：
3.8
作者：
Feng M;Yao G;Yu H;Qing Y;Wang K
通讯作者：
Wang K
影响因子：
4
作者：
Bertrand C;Valet P;Castan-Laurell I
通讯作者：
Castan-Laurell I
影响因子：
4.6
作者：
Folino, Anna;Montarolo, Pier Giorgio;Rastaldo, Raffaella
通讯作者：
Rastaldo, Raffaella
OSdlbcl：基于弥漫性大 B 细胞淋巴瘤基因表达谱的在线共识生存分析网络服务器
影响因子：
4
作者：
Dong, Huan;Wang, Qiang;Guo, Xiangqian
通讯作者：
Guo, Xiangqian