Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
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DOI：
10.2188/jea.je20100139
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发表时间：
2011
影响因子：
4.7
通讯作者：
J-MICC Study Group
中科院分区：
文献类型：
--
作者：
Wakai K;Hamajima N;Okada R;Naito M;Morita E;Hishida A;Kawai S;Nishio K;Yin G;Asai Y;Matsuo K;Hosono S;Ito H;Watanabe M;Kawase T;Suzuki T;Tajima K;Tanaka K;Higaki Y;Hara M;Imaizumi T;Taguchi N;Nakamura K;Nanri H;Sakamoto T;Horita M;Shinchi K;Kita Y;Turin TC;Rumana N;Matsui K;Miura K;Ueshima H;Takashima N;Nakamura Y;Suzuki S;Ando R;Hosono A;Imaeda N;Shibata K;Goto C;Hattori N;Fukatsu M;Yamada T;Tokudome S;Takezaki T;Niimura H;Hirasada K;Nakamura A;Tatebo M;Ogawa S;Tsunematsu N;Chiba S;Mikami H;Kono S;Ohnaka K;Takayanagi R;Watanabe Y;Ozaki E;Shigeta M;Kuriyama N;Yoshikawa A;Matsui D;Watanabe I;Inoue K;Ozasa K;Mitani S;Arisawa K;Uemura H;Hiyoshi M;Takami H;Yamaguchi M;Nakamoto M;Takeda H;Kubo M;Tanaka H;J-MICC Study Group
大多数疾病被认为是由环境因素和宿主基因型之间的相互作用引起的。为了检测生活方式相关疾病（尤其是癌症）发展过程中基因与环境的相互作用，日本多机构协作队列 (J-MICC) 研究于 2005 年启动。我们发起了一项横断面研究，通过问卷调查和体检评估基因型与生活方式和临床因素的关联。这 4519 名受试者是从日本 10 个地区的 J-MICC 研究参与者中选出的。总共选择了 108 个多态性，并使用 Invader 测定进行了基因分型。研究小组由 2124 名男性和 2395 名女性组成，基线时平均年龄为 55.8 ± 8.9 岁（范围为 35-69 岁）。在检查的 108 个多态性中，有 4 个在我们的研究人群中不具有多态性。在其余 104 个多态性中，大多数变异是常见的（96 个多态性的次要等位基因频率≥0.05）。该人群的等位基因频率与来自东京的 45 名日本人的 HapMap-JPT 数据集中的等位基因频率相当。 88 个多态性中只有 5 个显示等位基因频率差异大于 0.1。在 108 个多态性中，有 32 个在研究区域之间的次要等位基因频率显示出高度显着差异（P < 0.001）。这种关于生活方式和临床因素的全面数据收集将有助于阐明基因与环境的相互作用。此外，它可能是一个信息丰富的参考工具，因为大量日本人口的基因型数据的免费获取并不容易获得。
Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005. We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay. The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35–69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001). This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene–environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.
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影响因子：
4.7
作者：
Hara M;Higaki Y;Imaizumi T;Taguchi N;Nakamura K;Nanri H;Sakamoto T;Horita M;Shinchi K;Tanaka K
通讯作者：
Tanaka K
影响因子：
9.8
作者：
Yamaguchi-Kabata, Yumi;Nakazono, Kazuyuki;Kamatani, Naoyuki
通讯作者：
Kamatani, Naoyuki
影响因子：
4.7
作者：
Imaeda N;Goto C;Tokudome Y;Hirose K;Tajima K;Tokudome S
通讯作者：
Tokudome S
DOI：
10.1080/11026480600568720
发表时间：
2006-01-01
期刊：
Scandinavian Journal of Food & Nutrition
影响因子：
--
作者：
Goto, C.;Tokudome, Y.;Tokudome, S.
通讯作者：
Tokudome, S.
影响因子：
4.7
作者：
Tokudome Y;Goto C;Imaeda N;Hasegawa T;Kato R;Hirose K;Tajima K;Tokudome S
通讯作者：
Tokudome S