Calcific aortic valve disease and aortic atherosclerosis--two faces of the same disease?
Calcific aortic valve disease and aortic atherosclerosis--two faces of the same disease?
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主动脉瓣钙化病和主动脉粥样硬化——同一种疾病的两个方面？
DOI：
--
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Jurcut
中科院分区：
文献类型：
--
作者：
C. Ginghinǎ;A. Florian;C. Beladan;M. Iancu;A. Calin;B. Popescu;R. Jurcut
钙化性（退行性）主动脉瓣疾病是获得性主动脉瓣狭窄最常见的病因。从历史上看，它被认为是一种退行性的，“老年样”的过程，由主动脉瓣的老化-“磨损和撕裂”引起。然而，一些证据表明，钙化性瓣膜病不仅仅是由于年龄相关的退行性变，而是一种活动性疾病过程，具有可识别的起始因素、临床和遗传风险因素以及介导疾病进展的细胞和分子途径。组织学上，主动脉瓣硬化的早期病变类似于动脉粥样硬化斑块。此外，动脉粥样硬化危险因素和临床动脉粥样硬化性心血管疾病与主动脉硬化独立相关，表明它代表了涉及主动脉瓣的动脉粥样硬化样过程。到目前为止，唯一确定的治疗症状性主动脉瓣狭窄的方法是瓣膜置换术。可以改变或降低发展主动脉瓣疾病的可能性的较新疗法是高度期望的，并且目前正在研究中。在这篇文章中，我们试图回顾钙化性主动脉瓣疾病的现有数据，从组织学和致病方面，并完成与治疗的影响，以表征其与动脉粥样硬化过程的关系。
Calcific (degenerative) aortic valve disease is the most common etiology of acquired aortic valve stenosis. Historically, it was seen as a degenerative, "senile-like" process, resulting from aging--"wearing and tearing"--of the aortic valve. However, several lines of evidence suggest that calcific valve disease is not simply due to age-related degeneration but, rather, it is an active disease process with identifiable initiating factors, clinical and genetic risk factors, and cellular and molecular pathways that mediate disease progression. Histopathologically, the early lesions of aortic valve sclerosis resemble arterial atherosclerotic plaques. Furthermore, atherosclerotic risk factors and clinical atherosclerotic cardiovascular disease are independently associated with aortic sclerosis suggesting that it represents an atherosclerosis-like process involving the aortic valve. Until now, the only established treatment for symptomatic aortic valve stenosis has been valve replacement. Newer therapies that may modify or reduce the likelihood of developing aortic valve disease are highly desirable and are currently under investigation. In this article we tried to review the available data on calcific aortic valve disease, starting from histological and pathogenic aspects and finishing with therapeutic implications, in order to characterize its relationship with the atherosclerotic process.
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影响因子：
15.9
作者：
GALIS, ZS;SUKHOVA, GK;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
0.9
作者：
R. Ross
通讯作者：
R. Ross
DOI：
--
发表时间：
1991
期刊：
The American journal of pathology
影响因子：
--
作者：
Zand,T;Majno,G;Nunnari,JJ;Hoffman,AH;Savilonis,BJ;MacWilliams,B;Joris,I
通讯作者：
Joris,I
DOI：
10.1016/s0735-1097(01)01422-x
发表时间：
2001-09-01
影响因子：
24
作者：
Agmon, Y;Khandheria, BK;Tajik, AJ
通讯作者：
Tajik, AJ
影响因子：
5.3
作者：
Agmon, Y;Khandheria, BK;Meissner, I
通讯作者：
Meissner, I