Immunohistochemical evaluation of hypoxia markers in the myocardium

Immunohistochemical evaluation of hypoxia markers in the myocardium
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心肌缺氧标志物的免疫组织化学评估

DOI:
10.1080/00450618.2014.906653
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发表时间:
2014
影响因子:
1
通讯作者:
Kasuji Nishi
Kasuji Nishi
中科院分区:
医学4区
文献类型:
--
作者:
Satomu Morita;Satoshi Furukawa;Kasuji Nishi

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一些蛋白质被称为低氧标志物,在包括缺血细胞在内的低氧细胞中高表达。我们评估了各种缺氧标志物的表达时间及其在不同死因的心肌中表达的特异性。我们从我科进行的法医尸检中为每个死因选择了两例,并评估了缺氧标志物在心肌中的弥漫性表达。我们还评估了这些标志物在五例心脏性猝死患者的脑室中的局部表达。我们发现,心肌中缺氧标志物的表达随死亡原因和死亡过程的长短而不同。这些信息可能有助于法医学中确定死因。特别是,我们确定RBM3和CCC9是缺血性心脏病的标志物。心肌低氧标志物免疫组织化学染色有助于发现死亡原因。
Some proteins, termed hypoxia markers, are more highly expressed in hypoxic cells including ischemic cells. We evaluated the timing of the expression of various hypoxia markers and their specificity of expression in the myocardium in various causes of death. We selected two cases for each cause of death from the forensic autopsies performed by our department and evaluated the diffuse expression of hypoxia markers in the myocardium. We also evaluated the focal expression of these markers in the ventricles of five sudden cardiac death cases. We found that the expression of hypoxia markers in the myocardium varied depending on the cause of death and length of the dying process. This information may help in determining the cause of death in forensic medicine. In particular, we identified RBM3 and CCC9 as markers for ischemic heart disease. Immunohistological staining of myocardium with hypoxia markers could help to find the cause leading to death.
致命一氧化碳暴露后心肌中与缺氧、应激和细胞凋亡相关的抗原的表达
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者:
Satomu Morita;S. Furukawa;Lisa Wingenfeld;K. Nishi
通讯作者: K. Nishi
DOI: 10.1043/1543-2165-134.2.256
发表时间: 2010-02-01
影响因子: 4.6
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DOI: 10.4323/rjlm.2013.219
发表时间: 2013
影响因子: 0.4
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