Subcortical rather than cortical sources of the frequency-following response (FFR) relate to speech-in-noise perception in normal-hearing listeners.
Subcortical rather than cortical sources of the frequency-following response (FFR) relate to speech-in-noise perception in normal-hearing listeners.
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DOI：
10.1016/j.neulet.2021.135664
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发表时间：
2021-02-16
影响因子：
2.5
通讯作者：
Momtaz S
中科院分区：
文献类型：
--
作者：
Bidelman GM;Momtaz S
头皮记录的频率跟随反应（FFR）反映了听觉通路上锁相活动的混合。FFR已被广泛用作复杂听力技能的神经晴雨表，特别是噪声中语音（SIN）感知。将单独优化的源重建应用于通过EEG（FFREEG）记录的语音FFR，我们评估了皮层下[听神经（AN），脑干/中脑（BS）]和皮层[双侧初级听皮层，PAC]源发生器的相对贡献，目的是确定哪些源驱动FFR和SIN听力技能之间的大脑行为关系。我们发现FFR强度从AN到PAC急剧下降，与沿听觉神经轴上行沿着锁相减弱一致。语音基频（F0）的FFR对跨源噪声具有鲁棒性，但在皮层下源中最大（BS > AN > PAC）。PAC FFR仅在本底噪声以上且仅在语音的低音调（F0 ≤ 100 Hz）下观察到微弱的变化。脑行为回归显示（i）AN和BS FFR足以描述听者的QuickSIN评分，（ii）与神经磁（MEG）FFR相反，左侧和右侧PAC FFREEG均与SIN性能无关。我们的研究结果表明，皮层下的来源不仅占主导地位的电血流储备分数，但也语音血流储备分数和SIN处理在正常听力成人之间的联系，在以前的EEG研究中观察到。
Scalp-recorded frequency-following responses (FFRs) reflect a mixture of phase-locked activity across the auditory pathway. FFRs have been widely used as a neural barometer of complex listening skills, especially speech-in noise (SIN) perception. Applying individually optimized source reconstruction to speech-FFRs recorded via EEG (FFREEG), we assessed the relative contributions of subcortical [auditory nerve (AN), brainstem/midbrain (BS)] and cortical [bilateral primary auditory cortex, PAC] source generators with the aim of identifying which source(s) drive the brain-behavior relation between FFRs and SIN listening skills. We found FFR strength declined precipitously from AN to PAC, consistent with diminishing phase-locking along the ascending auditory neuroaxis. FFRs to the speech fundamental (F0) were robust to noise across sources, but were largest in subcortical sources (BS > AN > PAC). PAC FFRs were only weakly observed above the noise floor and only at the low pitch of speech (F0≈100 Hz). Brain-behavior regressions revealed (i) AN and BS FFRs were sufficient to describe listeners’ QuickSIN scores and (ii) contrary to neuromagnetic (MEG) FFRs, neither left nor right PAC FFREEG related to SIN performance. Our findings suggest subcortical sources not only dominate the electrical FFR but also the link between speech-FFRs and SIN processing in normal-hearing adults as observed in previous EEG studies.
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影响因子：
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