Modulation of subgenual anterior cingulate cortex activity with real-time neurofeedback.
Modulation of subgenual anterior cingulate cortex activity with real-time neurofeedback.
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DOI：
10.1002/hbm.20997
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发表时间：
2011-01
影响因子：
4.8
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Hamilton, J. Paul;Glover, Gary H.;Hsu, Jung-Jiin;Johnson, Rebecca F.;Gotlib, Ian H.
实时神经反馈技术的出现使我们能够开始描绘大脑中感觉和认知以及最近的情感中心的可控性。亚膝前扣带回皮质(SACC)被认为与情感状态的产生有关，并与精神病理学有关。在这项研究中，我们研究了个体是否可以使用实时功能磁共振神经反馈来调节SACC的活动。在一项用于识别感兴趣SACC区域的定位任务之后，一组8名女性参与了四次扫描：(1)训练前扫描，要求她们在没有神经反馈的情况下减少SACC的活动；(2)两次训练扫描，其中SACC神经反馈与减少SACC活动的说明一起提供；(3)训练后扫描，无神经反馈。另有9名女性在轭反馈控制组中看到了来自试验组参与者的SACC活动。在神经反馈训练过程中，实验组SACC的活性显著降低，而对照组则没有。然而，实验组的这种训练效果并不适用于无神经反馈的训练后扫描。心理生理交互作用分析显示，与假对照组相比，实验组在神经反馈训练期间SACC和后扣带皮质活动之间的相关性低于无神经反馈扫描。个体可以下调SACC的发现表明，功能异常与情感障碍密切相关的初级情绪中枢可以通过神经反馈来控制。
The advent of real-time neurofeedback techniques has allowed us to begin to map the controllability of sensory and cognitive and, more recently, affective centers in the brain. The subgenual anterior cingulate cortex (sACC) is thought to be involved in generation of affective states and has been implicated in psychopathology. In this study, we examined whether individuals could use realtime fMRI neurofeedback to modulate sACC activity. Following a localizer task used to identify an sACC region of interest, an experimental group of eight women participated in four scans: (1) a pretraining scan in which they were asked to decrease activity in the sACC without neurofeedback; (2) two training scans in which sACC neurofeedback was presented along with instructions to decrease sACC activity; and (3) a neurofeedback-free post-training scan. An additional nine women in a yoked feedback control group saw sACC activity from the participants in the experimental group. Activity in the sACC was significantly reduced during neurofeedback training in the experimental group, but not in the control group. This training effect in the experimental group, however, did not generalize to the neurofeedback-free post-training scan. A psychophysiological interaction analysis showed decreased correlation in the experimental group relative to the sham control group between activity in the sACC and the posterior cingulate cortex during neurofeedback training relative to neurofeedback-free scans. The finding that individuals can down-modulate the sACC shows that a primary emotion center in which functional abnormality has been strongly implicated in affective disorders can be controlled with the aid of neurofeedback.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
Mackey, SC
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.