Rapid hydrothermal flow synthesis and characterisation of carbonate- and silicate-substituted calcium phosphates.
Rapid hydrothermal flow synthesis and characterisation of carbonate- and silicate-substituted calcium phosphates.
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DOI：
10.1177/0885328212460289
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发表时间：
2013-09
影响因子：
2.9
通讯作者：
Darr JA
中科院分区：
文献类型：
--
作者：
Chaudhry AA;Knowles JC;Rehman I;Darr JA
采用连续水热流动合成技术成功制备了一系列结晶和纳米尺寸的碳酸盐和硅酸盐取代的羟基磷灰石。与纯相羟基磷灰石相比，离子取代的磷酸钙是骨替代应用的更好候选物（由于生物活性提高）。使用尿素作为碳酸盐源来合成具有约5wt%取代的碳酸盐含量的相纯碳酸化羟基磷灰石（CO 3-HA）（样品7.5CO3-HA），并且发现溶液中尿素浓度的进一步增加导致碳酸盐取代的羟基磷灰石和碳酸钙的两相混合物。透射电子显微镜图像显示，随着尿素浓度的增加，羟基磷灰石的粒径减小。能量色散X射线光谱结果显示样品7.5CO3-HA中的Ca：P摩尔比为1.45（±0.04）的缺钙磷灰石。对于硅酸盐取代的羟基磷灰石（SiO 4-HA），使用乙酸硅作为硅酸盐离子源。据观察，在连续水热流合成系统中，SiO 4-HA的合成存在约1.1wt%的取代阈值，这可能是由于随着乙酸硅浓度的逐渐增加，产率降低。使用包括透射电子显微镜、X射线粉末衍射、差示扫描量热法、热重分析、拉曼光谱和傅里叶变换红外光谱的技术分析所有的沉淀粉末（没有任何额外的热处理）。
A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to phase-pure hydroxyapatite. Urea was used as a carbonate source for synthesising phase pure carbonated hydroxyapatite (CO3-HA) with ≈5 wt% substituted carbonate content (sample 7.5CO3-HA) and it was found that a further increase in urea concentration in solution resulted in biphasic mixtures of carbonate-substituted hydroxyapatite and calcium carbonate. Transmission electron microscopy images revealed that the particle size of hydroxyapatite decreased with increasing urea concentration. Energy-dispersive X-ray spectroscopy result revealed a calcium deficient apatite with Ca:P molar ratio of 1.45 (±0.04) in sample 7.5CO3-HA. For silicate-substituted hydroxyapatite (SiO4-HA) silicon acetate was used as a silicate ion source. It was observed that a substitution threshold of ∼1.1 wt% exists for synthesis of SiO4-HA in the continuous hydrothermal flow synthesis system, which could be due to the decreasing yields with progressive increase in silicon acetate concentration. All the as-precipitated powders (without any additional heat treatments) were analysed using techniques including Transmission electron microscopy, X-ray powder diffraction, Differential scanning calorimetry, Thermogravimetric analysis, Raman spectroscopy and Fourier transform infrared spectroscopy.
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影响因子：
9.7
作者：
Chaudhry, Aqif A.;Yan, Haixue;Darr, Jawwad A.
通讯作者：
Darr, Jawwad A.
影响因子：
3.8
作者：
Gong, K.;Braden, M.;Darr, J. A.
通讯作者：
Darr, J. A.
影响因子：
4.9
作者：
Chaudhry, Aqif A.;Haque, Saba;Darr, Jawwad A.
通讯作者：
Darr, Jawwad A.
DOI：
10.1002/jbm.10044
发表时间：
2002-03-15
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Gibson, IR;Bonfield, W
通讯作者：
Bonfield, W
影响因子：
9.5
作者：
Gribov, Evgueni N.;Parkhomchuk, Ekaterina V.;Okunev, Alexey G.
通讯作者：
Okunev, Alexey G.