Advanced glycation/glycoxidation endproduct carboxymethyl-lysine and incidence of coronary heart disease and stroke in older adults.
Advanced glycation/glycoxidation endproduct carboxymethyl-lysine and incidence of coronary heart disease and stroke in older adults.
复制标题
DOI：
10.1016/j.atherosclerosis.2014.04.013
复制
发表时间：
2014-07
期刊：
影响因子：
5.3
通讯作者：
Zieman, Susan J.
中科院分区：
文献类型：
--
作者：
Kizer, Jorge R.;Benkeser, David;Arnold, Alice M.;Ix, Joachim H.;Mukamal, Kenneth J.;Djousse, Luc;Tracy, Russell P.;Siscovick, David S.;Psaty, Bruce M.;Zieman, Susan J.
关键词：
晚期糖基化/糖氧化终末产物(AGEs)在氧化应激增加的环境中积累--如糖尿病、慢性肾脏疾病和衰老--在这些环境中，它们促进血管僵硬和动脉粥样硬化形成，但AGEs与老年人心血管事件之间的预期关联以前没有被研究过。为了验证循环中的N-ε-羧甲基赖氨酸(主要年龄)水平会增加老年人发生冠心病和中风的风险这一假设，我们用免疫分析法检测了2,111名没有普遍心血管疾病的人的血清CML，这些人参与了一项以人群为基础的研究，对象是65岁及以上的美国成年人。在中位数为9.1年的随访期间，共发生了625例心血管事件。在调整了年龄、性别、种族、收缩压、抗高血压治疗、糖尿病、吸烟状况、甘油三酯、白蛋白和自我报告的健康状况后，慢性粒细胞白血病与心血管事件的发生呈正相关(每SD[HR][0.99pmol/L]增加=1.11，95%可信区间[CI]=1.03~1.19)。C反应蛋白、估计的肾小球滤过率(EGFR)和尿白蛋白/肌酐比率的额外调整并没有实质性地减弱这种相关性。冠心病和中风的成分终点的研究结果类似。在这个庞大的老年队列中，慢性粒细胞白血病与心血管事件的风险增加有关，独立于一系列潜在的混杂因素和介体。尽管适度的相关性限制了慢性粒细胞白血病在风险预测方面的价值，但这些基于社区的发现为临床试验提供了支持，以测试在这一人群中用于心血管预防的降龄疗法。
Advanced glycation/glycoxidation endproducts (AGEs) accumulate in settings of increased oxidative stress – such as diabetes, chronic kidney disease and aging – where they promote vascular stiffness and atherogenesis, but the prospective association between AGEs and cardiovascular events in elders has not been previously examined. To test the hypothesis that circulating levels of Nε-carboxymethyl-lysine (CML), a major AGE, increase the risk of incident coronary heart disease and stroke in older adults, we measured serum CML by immunoassay in 2,111 individuals free of prevalent cardiovascular disease participating in a population-based study of U.S. adults ages 65 and older. During median follow-up of 9.1 years, 625 cardiovascular events occurred. CML was positively associated with incident cardiovascular events after adjustment for age, sex, race, systolic blood pressure, anti-hypertensive treatment, diabetes, smoking status, triglycerides, albumin, and self-reported health status (hazard ratio [HR] per SD [0.99 pmol/l] increase = 1.11, 95% confidence interval [CI]=1.03–1.19). This association was not materially attenuated by additional adjustment for C-reactive protein, estimated glomerular filtration rate (eGFR), and urine albumin/creatinine ratio. Findings were similar for the component endpoints of coronary heart disease and stroke. In this large older cohort, CML was associated with an increased risk of cardiovascular events independent of a wide array of potential confounders and mediators. Although the moderate association limits CML’s value for risk prediction, these community-based findings provide support for clinical trials to test AGE-lowering therapies for cardiovascular prevention in this population.
登录
查看更多内容
影响因子：
2.9
作者：
REDDY, S;BICHLER, J;BAYNES, JW
通讯作者：
BAYNES, JW
影响因子：
19.6
作者：
Busch, M;Franke, S;Stein, G
通讯作者：
Stein, G
影响因子：
8.2
作者：
Kilhovd, B. K.;Juutilainen, A.;Laakso, M.
通讯作者：
Laakso, M.
影响因子：
4.2
作者：
Semba, Richard D.;Arab, Lenore;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
5
作者：
Kizer, Jorge R.;Biggs, Mary L.;Siscovick, David S.
通讯作者：
Siscovick, David S.