Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
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DOI：
10.1111/j.1365-2796.2009.02156.x
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发表时间：
2009-10
影响因子：
11.1
通讯作者：
Kushner JA
中科院分区：
文献类型：
--
作者：
Granger A;Kushner JA
β细胞再生代表了糖尿病治疗的主要目标。在胰腺再生过程中揭开β细胞的起源可能有助于恢复糖尿病患者的功能性β细胞群。这个科学问题代表了一个长期的兴趣，今天仍然在深入研究。这篇评论的重点是几百年前的开创性观察和随后的理论，并描述了技术创新如何帮助解决这些早期研究者产生的一些争议，但不是全部。在世纪末，完整的胰腺切除术证明了胰腺的重要生理作用及其与糖尿病的联系。胰腺损伤模型，包括胰腺切除术和导管结扎术，使研究人员能够描述胰岛功能和评估胰腺的再生能力。提出了三个主要理论来解释新形成的胰岛的起源：1）腺泡细胞转分化成胰岛，2）胰岛新生，一个让人想起胚胎发育期间胰岛形成的过程，以及3）预先存在的胰岛细胞的复制。尽管在过去的50年里有相当多的技术创新，但新的成人β细胞的起源仍然存在很大的争议，今天仍然有同样的三种理论在争论。
Beta cell regeneration represents a major goal of therapy for diabetes. Unraveling the origin of beta cells during pancreatic regeneration could help restore a functional beta cell mass in diabetes patients. This scientific question has represented a longstanding interest still intensively investigated today. This review focuses on pioneering observations and subsequent theories made hundred years ago and describes how technical innovation helped resolve some, but not all, of the controversies generated by these early investigators. At the end of the nineteenth century, complete pancreatectomy demonstrated the crucial physiological role of the pancreas and its link to diabetes. Pancreatic injury models, including pancreatectomy and ductal ligation, allowed investigators to describe islet function and to assess the regenerative capacity of the pancreas. Three main theories were proposed to explain the origins of newly formed islets: 1) transdifferentiation of acinar cells into islets, 2) islet neogenesis, a process reminiscent of islet formation during embryonic development, and 3) replication of preexisting islet cells. Despite considerable technical innovation in the last fifty years, the origin of new adult beta cells remains highly controversial and the same three theories are still debated today.
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影响因子：
9.8
作者：
Brennand K;Huangfu D;Melton D
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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DOI：
10.1098/rstb.1905.0004
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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