High prevalence of antibiotic resistance in commensal Escherichia coli among children in rural Vietnam.
High prevalence of antibiotic resistance in commensal Escherichia coli among children in rural Vietnam.
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DOI：
10.1186/1471-2334-12-92
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发表时间：
2012-04-18
影响因子：
3.7
通讯作者：
Lundborg CS
中科院分区：
文献类型：
--
作者：
Dyar OJ;Hoa NQ;Trung NV;Phuc HD;Larsson M;Chuc NT;Lundborg CS
共生菌是抗生素耐药基因的重要储存库。在东南亚，很少进行以社区为基础的共生菌抗生素耐药性研究。我们调查了越南农村学龄前儿童共生大肠杆菌的耐药性患病率，以及与耐药菌携带相关的因素。我们从居住在河内附近的人口监测点FilaBavi的818名6-60个月儿童的粪便样本中检测了大肠杆菌分离株。在抽样前三周，收集了参与儿童的每日抗生素使用数据，并根据2007年FilaBavi重新人口普查中提取的社会经济和人口统计学特征进行分析。产生描述性统计数据，并使用逻辑回归模型来确定被检查因素的贡献。对四环素（74%）、复方新诺明（68%）、氨苄西林（65%）、氯霉素（40%）和萘啶酸（27%）的耐药率较高。2株对环丙沙星耐药。60%的分离株对三种或更多种抗生素具有耐药性。近期磺胺使用与复方新诺明耐药性相关[OR 3.2, 95% CI 1.8-5.7]， β -内酰胺使用与氨苄西林耐药性相关[OR 1.8, 95% CI 1.3-2.4]。6-23月龄儿童分离株更可能对氨苄西林耐药[OR 1.8, 95% CI 1.3-2.4]和复方新诺明耐药[OR 1.5, 95% CI 1.1-2.0]。确定了地理区域与四环素和氨苄西林耐药之间的关系。我们提出高流行的携带共生大肠杆菌耐常用抗生素。已确定的与近期抗生素使用、年龄和地理位置的关联可能有助于我们了解耐抗生素共生菌的携带情况。
Commensal bacteria represent an important reservoir of antibiotic resistance genes. Few community-based studies of antibiotic resistance in commensal bacteria have been conducted in Southeast Asia. We investigated the prevalence of resistance in commensal Escherichia coli in preschool children in rural Vietnam, and factors associated with carriage of resistant bacteria. We tested isolates of E. coli from faecal samples of 818 children aged 6-60 months living in FilaBavi, a demographic surveillance site near Hanoi. Daily antibiotic use data was collected for participating children for three weeks prior to sampling and analysed with socioeconomic and demographic characteristics extracted from FilaBavi's re-census survey 2007. Descriptive statistics were generated, and a logistic regression model was used to identify contributions of the examined factors. High prevalences of resistance were found to tetracycline (74%), co-trimoxazole (68%), ampicillin (65%), chloramphenicol (40%), and nalidixic acid (27%). Two isolates were resistant to ciprofloxacin. Sixty percent of isolates were resistant to three or more antibiotics. Recent sulphonamide use was associated with co-trimoxazole resistance [OR 3.2, 95% CI 1.8-5.7], and beta-lactam use with ampicillin resistance [OR 1.8, 95% CI 1.3-2.4]. Isolates from children aged 6-23 months were more likely to be resistant to ampicillin [OR 1.8, 95% CI 1.3-2.4] and co-trimoxazole [OR 1.5, 95% CI 1.1-2.0]. Associations were identified between geographical areas and tetracycline and ampicillin resistance. We present high prevalence of carriage of commensal E. coli resistant to commonly used antibiotics. The identified associations with recent antibiotic use, age, and geographical location might contribute to our understanding of carriage of antibiotic resistant commensal bacteria.
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影响因子：
6.4
作者：
FORNASINI, M;REVES, RR;PICKERING, LK
通讯作者：
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影响因子：
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