Differential transforming activity of the retroviral Tax oncoproteins in human T lymphocytes.
Differential transforming activity of the retroviral Tax oncoproteins in human T lymphocytes.
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DOI：
10.3389/fmicb.2013.00287
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发表时间：
2013
影响因子：
5.2
通讯作者：
Cheng H
中科院分区：
文献类型：
--
作者：
Ren T;Cheng H
人T细胞白血病病毒1型和2型（HTLV-1和-2）是两种密切相关的逆转录病毒。HTLV-1引起成人T细胞白血病和淋巴瘤，而HTLV-2感染与人类疾病在病因学上没有联系。HTLV-1和htlv -2的病毒基因组分别编码高度同源的转化蛋白tax1和tax2。Tax-1被认为在转化CD4+ T淋巴细胞中起核心作用。tax1的表达对于促进病毒感染的人T淋巴细胞的存活和增殖至关重要，并且是启动htlv -1介导的肿瘤发生所必需的。在转基因小鼠和人源化小鼠模型中，tax1已被证明具有致白血病作用。虽然tax1能够有效转化啮齿动物成纤维细胞并在小鼠模型中诱导淋巴瘤，但它很少转化人类原代CD4+ T淋巴细胞。相比之下，tax2有效地使人CD4+ T细胞永生化，尽管它在啮齿动物细胞中的转化活性比tax1低。我们在此讨论我们最近对人类T细胞中tax1和tax2的差异转化活性的观察和看法。
Human T cell leukemia virus type 1 and type 2 (HTLV-1 and -2) are two closely related retroviruses. HTLV-1 causes adult T cell leukemia and lymphoma, whereas HTLV-2 infection is not etiologically linked to human disease. The viral genomes of HTLV-1 and -2 encode highly homologous transforming proteins, Tax-1 and Tax-2, respectively. Tax-1 is thought to play a central role in transforming CD4+ T lymphocytes. Expression of Tax-1 is crucial for promoting survival and proliferation of virally infected human T lymphocytes and is necessary for initiating HTLV-1-mediated oncogenesis. In transgenic mice and humanized mouse model, Tax-1 has proven to be leukemogenic. Although Tax-1 is able to efficiently transform rodent fibroblasts and to induce lymphoma in mouse model, it rarely transforms primary human CD4+ T lymphocytes. In contrast, Tax-2 efficiently immortalizes human CD4+ T cells though it exhibits a lower transforming activity in rodent cells as compared to Tax-1. We here discuss our recent observation and views on the differential transforming activity of Tax-1 and Tax-2 in human T cells.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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发表时间：
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