Immune System Investigation Using Parasitic Helminths.
Immune System Investigation Using Parasitic Helminths.
复制标题
DOI：
10.1146/annurev-immunol-093019-122827
复制
发表时间：
2021-04-26
影响因子：
29.7
通讯作者：
Herbert DR
中科院分区：
文献类型：
--
作者：
Douglas B;Oyesola O;Cooper MM;Posey A;Tait Wojno E;Giacomin PR;Herbert DR
人类和蠕虫之间的共同进化适应已经在宿主免疫和由于免疫调节的慢性寄生之间形成了一种微调的平衡。考虑到这些相互作用力驱动选择，蠕虫感染的实验模型非常适合于发现宿主保护性免疫反应如何适应这些大型后生动物寄生虫所居住的独特组织小生境。这篇综述强调了过去十年来蠕虫感染免疫学的关键发现，从先天淋巴细胞到神经免疫连接的重要性。特别强调蠕虫免疫学中最有可能增长的新兴领域，包括寄生虫遗传操作的出现，以研究免疫学和使用工程T细胞进行治疗选择。最后，我们介绍了蠕虫作为自身免疫性疾病治疗的人类挑战试验的现状，这些试验将使寄生虫的研究在未来几年保持在免疫学的最前沿。
Coevolutionary adaptation between humans and helminths has developed a finely tuned balance between host immunity and chronic parasitism due to immunoregulation. Given that these reciprocal forces drive selection, experimental models of helminth infection are ideally suited for discovering how host protective immune responses adapt to the unique tissue niches inhabited by these large metazoan parasites. This review highlights the key discoveries in the immunology of helminth infection made over the last decade, from innate lymphoid cells to the emerging importance of neuroimmune connections. A particular emphasis is placed on the emerging areas within helminth immunology where the most growth is possible, including the advent of genetic manipulation of parasites to study immunology and the use of engineered T cells for therapeutic options. Lastly, we cover the status of human challenge trials with helminths as treatment for autoimmune disease, which taken together, stand to keep the study of parasitic worms at the forefront of immunology for years to come.
登录
查看更多内容
影响因子：
20.3
作者：
Balla, Keir M.;Lugo-Villarino, Geanncarlo;Traver, David
通讯作者：
Traver, David
影响因子：
15.3
作者：
Campbell, Laura;Hepworth, Matthew R.;Grencis, Richard K.
通讯作者：
Grencis, Richard K.
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cardoso V;Chesné J;Ribeiro H;García-Cassani B;Carvalho T;Bouchery T;Shah K;Barbosa-Morais NL;Harris N;Veiga-Fernandes H
通讯作者：
Veiga-Fernandes H
影响因子：
64.8
作者：
BOMAN, HG;NILSSON, I;RASMUSON, B
通讯作者：
RASMUSON, B