Incidence of endometriosis by study population and diagnostic method: the ENDO study.

Incidence of endometriosis by study population and diagnostic method: the ENDO study.
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DOI:
10.1016/j.fertnstert.2011.05.087
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发表时间:
2011-08
影响因子:
6.7
通讯作者:
Giudice, Linda C.
Giudice, Linda C.
中科院分区:
医学2区
文献类型:
--
作者:
Louis, Germaine M. Buck;Hediger, Mary L.;Peterson, C. Matthew;Croughan, Mary;Sundaram, Rajeshwari;Stanford, Joseph;Chen, Zhen;Fujimoto, Victor Y.;Varner, Michael W.;Trumble, Ann;Giudice, Linda C.

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To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond clinical care. Matched exposure cohort design. Surgical centers in the Salt Lake City, Utah and San Francisco, California areas. The operative cohort comprised 495 women undergoing laparoscopy/laparotomy between 2007–2009, while the population cohort comprised 131 women from the surgical centers’ catchment areas. None Incidence of endometriosis by diagnostic method in the operative cohort and by pelvic magnetic resonance imaged (MRI) disease in the population cohort. Endometriosis incidence in the operative cohort ranged by two orders of magnitude by diagnostic method: 0.7% for only histology, 7% for only MRI and 41% for visualized disease. Endometriosis staging was skewed toward minimal (58%) and mild disease (15%). The incidence of MRI-diagnosed endometriosis was 11% in the population cohort. Endometriosis incidence is dependent upon the diagnostic method and choice of sampling framework. Conservatively, 11% of women have undiagnosed endometriosis at the population level with implications for the design and interpretation of etiologic research.
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