Gold nanoparticle hyperthermia reduces radiotherapy dose.
Gold nanoparticle hyperthermia reduces radiotherapy dose.
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DOI：
10.1016/j.nano.2014.05.006
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发表时间：
2014-11
影响因子：
5.4
通讯作者：
Smilowitz, Henry M.
中科院分区：
文献类型：
--
作者：
Hainfeld, James F.;Lin, Lynn;Slatkin, Daniel N.;Dilmanian, F. Avraham;Vadas, Timothy M.;Smilowitz, Henry M.
金纳米颗粒可以吸收近红外光，从而加热和消融肿瘤。金纳米颗粒也被用于在放射治疗期间提高肿瘤的x射线剂量。热疗和放疗的结合是协同的，重要的是可以减少x射线剂量并改善治疗效果。在这里，我们在肿瘤内注入小的15纳米金纳米颗粒，这些纳米颗粒经过改造，由红外透明转变为红外吸收，然后用红外线加热，然后用x射线治疗。协同作用研究使用非常耐辐射的皮下鳞状细胞癌（SCCVII）小鼠。结果发现，控制50%肿瘤所需的剂量，通常为55 Gy，可以降低到<15 Gy（因子为bbb3.7）。因此，金纳米颗粒提供了一种结合热疗和放疗的方法，大大减少了所需的x射线辐射，从而保留了正常组织，减少了副作用，并使放疗更有效。
Gold nanoparticles can absorb near infrared light, resulting in heating and ablation of tumors. Gold nanoparticles have also been used for enhancing the dose of X-rays in tumors during radiotherapy. The combination of hyperthermia and radiotherapy is synergistic, importantly allowing a reduction in X-ray dose with improved therapeutic results. Here we intratumorally infused small 15 nm gold nanoparticles engineered to be transformed from infrared-transparent to infrared-absorptive by the tumor, which were then heated by infrared followed by X-ray treatment. Synergy was studied using a very radioresistant subcutaneous squamous cell carcinoma (SCCVII) in mice. It was found that the dose required to control 50% of the tumors, normally 55 Gy, could be reduced to <15 Gy (a factor of >3.7). Gold nanoparticles therefore provide a method to combine hyperthermia and radiotherapy to drastically reduce the X-ray radiation needed, thus sparing normal tissue, reducing the side effects, and making radiotherapy more effective.
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影响因子：
13.3
作者：
Kong, Tao;Zeng, Jie;Xing, James Z.
通讯作者：
Xing, James Z.
影响因子：
3.5
作者：
Cho, SH
通讯作者：
Cho, SH
DOI：
10.1073/pnas.91.6.2076
发表时间：
1994-03-15
影响因子：
11.1
作者：
BOBO, RH;LASKE, DW;OLDFIELD, EH
通讯作者：
OLDFIELD, EH
影响因子：
3.5
作者：
McMahon, Stephen J.;Mendenhall, Marcus H.;Currell, Fred
通讯作者：
Currell, Fred
影响因子：
3.4
作者：
Horsman, M. R.;Overgaard, J.
通讯作者：
Overgaard, J.