Biasing the content of hippocampal replay during sleep.
Biasing the content of hippocampal replay during sleep.
复制标题
偏向睡眠期间海马重播的含量。
DOI：
10.1038/nn.3203
复制
发表时间：
2012-10
影响因子：
25
通讯作者：
Wilson, Matthew A.
中科院分区：
文献类型：
--
作者：
Bendor, Daniel;Wilson, Matthew A.
海马体在将自我经历的事件编码到记忆中起着至关重要的作用。在睡眠期间，海马体中与最近经历相关的神经活动被观察到自发地重新发生，并且这种“重放”被认为对记忆巩固很重要。任务相关的线索可以增强记忆巩固时，提出在训练后的睡眠期，如果记忆巩固海马重放，这种重放的具体增强也应观察。为了验证这一点，我们对大鼠进行了空间联想任务的训练，同时记录海马体中的神经元集合。在这里，我们报告说，在睡眠期间，一个任务相关的听觉线索偏向于重放与该线索相关的空间记忆的再激活事件。这些结果表明，睡眠重放可以通过外部刺激操纵，并为海马重放在记忆巩固中的作用提供了进一步的证据。
The hippocampus plays an essential role in encoding self-experienced events into memory. During sleep, neural activity in the hippocampus related to a recent experience has been observed to spontaneously reoccur, and this “replay” has been postulated to be important for memory consolidation. Task-related cues can enhance memory consolidation when presented during a post-training sleep session, and if memories are consolidated by hippocampal replay, a specific enhancement for this replay should also be observed. To test this, we have trained rats on an auditory-spatial association task, while recording from neuronal ensembles in the hippocampus. Here we report that during sleep, a task-related auditory cue biases reactivation events towards replaying the spatial memory associated with that cue. These results indicate that sleep replay can be manipulated by external stimulation, and provide further evidence for the role of hippocampal replay in memory consolidation.
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DOI：
10.1126/science.1179013
发表时间：
2009-11-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Rudoy JD;Voss JL;Westerberg CE;Paller KA
通讯作者：
Paller KA
影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
3.4
作者：
Schabus M;Dang-Vu TT;Heib DP;Boly M;Desseilles M;Vandewalle G;Schmidt C;Albouy G;Darsaud A;Gais S;Degueldre C;Balteau E;Phillips C;Luxen A;Maquet P
通讯作者：
Maquet P
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.