Stimulus Perception by Histidine Kinases

Stimulus Perception by Histidine Kinases
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组氨酸激酶的刺激感知

DOI:
10.1002/9781119004813.ch25
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发表时间:
2016
期刊:
影响因子:
--
通讯作者:
Heermann
Heermann
中科院分区:
--
文献类型:
--
作者:
Schramke;Heermann

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对于单细胞生物来说,适应不断变化的环境尤其具有挑战性。许多参数,如营养物质的可用性,不同离子的浓度,渗透压,温度和细胞密度必须被永久地感知,以允许细胞反应。在细菌中,适应不同环境的最常见方式是通过双组分信号转导。一个典型的双组分系统由一个组氨酸激酶和一个调节细胞反应的反应调节剂组成,组氨酸激酶在刺激感知时自磷酸化。尽管进行了广泛的研究,但在大多数情况下,组氨酸激酶感受到的刺激尚不清楚。然而,有一些特征良好的组氨酸激酶,已经探索了刺激感知和信号传导过程的分子机制,这些在本章中详细描述。
The adaptation to changing environments is especially challenging for unicellular organisms. Many parameters like availability of nutrients, concentration of different ions, osmolarity, temperature, and cell density have to be permanently sensed to allow a cellular response. In bacteria, the most common way to adapt to different environments is via two‐component signal transduction. A prototypical two‐component system consists of a histidine kinase, which autophosphorylates upon stimulus perception, and a response regulator mediating the cellular response. Despite extensive research, in most cases the stimulus sensed by the histidine kinase is not yet known. However, there are some well‐characterised histidine kinases, for which the molecular mechanism of stimulus perception and signalling process is already explored, and these are described in detail in this chapter.
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DOI: --
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期刊:
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