Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use.
Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use.
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DOI：
10.1016/j.jpsychires.2008.12.002
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发表时间：
2009-01
影响因子：
4.8
通讯作者：
Kumra S
中科院分区：
文献类型：
--
作者：
Ashtari M;Cervellione K;Cottone J;Ardekani BA;Sevy S;Kumra S
越来越多的证据表明青春期是神经元成熟的关键时期。尽管美国和国际上青少年和年轻人吸食大麻的比例很高，但人们对其对大脑发育的影响知之甚少。根据有关青春期正常大脑发育的神经影像学文献，我们假设大量使用大麻（HCU）的人在青春期后期发育的类似大脑区域会出现大脑结构异常，特别是额颞叶连接。招募了 14 名因大麻依赖而接受住院治疗的年轻成年男性和 14 名年龄匹配的健康男性对照受试者。患者在整个青春期都有 HCU 病史； 5人同时酗酒。受试者接受了结构和扩散张量磁共振成像。使用体素和纤维束成像分析比较受试者组之间的白质完整性。体素和纤维束成像分析显示，患有 HCU 的青少年的各向异性分数降低，径向扩散率增加，并且已知参与青春期后期持续发育的同源区域的迹线增加，特别是在通过弓状束的额颞叶连接中。我们的结果支持这样的假设：青春期大量使用大麻可能会影响正常大脑成熟的轨迹。由于 5 名 HCU 受试者同时饮酒，因此本研究的结论应被视为初步结论，因为此处报告的 DTI 结果可能反映了酒精和大麻的结合使用。需要对更大的样本进行进一步的纵向研究，并控制饮酒，以更好地了解大麻对发育中的大脑影响的病理生理学。
There is growing evidence that adolescence is a key period for neuronal maturation. Despite the high prevalence of marijuana use among adolescents and young adults in the United States and internationally, very little is known about its impact on the developing brain. Based on neuroimaging literature on normal brain developmental during adolescence, we hypothesized that individuals with heavy cannabis use (HCU) would have brain structure abnormalities in similar brain regions that undergo development during late adolescence, particularly the fronto-temporal connection. Fourteen young adult males in residential treatment for cannabis dependence and 14 age-matched healthy male control subjects were recruited. Patients had a history of HCU throughout adolescence; 5 had concurrent alcohol abuse. Subjects underwent structural and diffusion tensor magnetic resonance imaging. White matter integrity was compared between subject groups using voxelwise and fiber tractography analysis. Voxelwise and tractography analyses revealed that adolescents with HCU had reduced fractional anisotropy, increased radial diffusivity, and increased trace in the homologous areas known to be involved in ongoing development during late adolescence, particularly in the fronto-temporal connection via arcuate fasciculus. Our results support the hypothesis that heavy cannabis use during adolescence may affect the trajectory of normal brain maturation. Due to concurrent alcohol consumption in five HCU subjects, conclusions from this study should be considered preliminary, as the DTI findings reported here may be reflective of the combination of alcohol and marijuana use. Further research in larger samples, longitudinal in nature, and controlling for alcohol consumption is needed to better understand the pathophysiology of the effect of cannabis on the developing brain.
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影响因子：
4.2
作者：
Durazzo, Timothy C.;Cardenas, Valerie A.;Meyerhoff, Dieter J.
通讯作者：
Meyerhoff, Dieter J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6
作者：
Fergusson, DM;Boden, JM;Horwood, LJ
通讯作者：
Horwood, LJ
影响因子：
10.6
作者：
Caspi, A;Moffitt, TE;Craig, IW
通讯作者：
Craig, IW
影响因子：
3.6
作者：
Cha, Young May;White, Aaron M.;Swartzwelder, H. S.
通讯作者：
Swartzwelder, H. S.