Electromagnetic Fields for the Regulation of Neural Stem Cells.
Electromagnetic Fields for the Regulation of Neural Stem Cells.
复制标题
电磁场对神经干细胞的调节
DOI：
10.1155/2017/9898439
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发表时间：
2017
影响因子：
4.3
通讯作者：
Feng H
中科院分区：
文献类型：
--
作者：
Cui M;Ge H;Zhao H;Zou Y;Chen Y;Feng H
局部磁场（MF）可以很容易地穿透头皮，颅骨和脑膜，从而在中枢和外周神经系统中诱导电流，其主要用于经颅磁刺激（TMS），用于对在各种大脑活动中发挥作用的不同区域或细胞产生特定效应。重复经颅磁刺激（rTMS）的研究导致了新的有吸引力的治疗方法。成人脑内的神经干细胞具有自我更新和多向分化的能力，能够维持机体内环境的稳定和修复中枢神经系统急性损伤。本文就神经干细胞的电活动、电磁场的基本作用机制及其对神经干细胞增殖、分化、迁移和成熟的影响进行综述。尽管rTMS已被美国FDA批准用于难治性抑郁症患者，但rTMS在急性中枢神经系统损伤的临床应用中，尤其是作为一种康复策略对NSC的调节，仍存在机制和局限性。应进行更深入的研究，以提供详细的参数和机制的rTMS在进一步的研究，使其成为一个强大的工具，以治疗谁是生存与急性中枢神经系统损伤的人。
Localized magnetic fields (MFs) could easily penetrate the scalp, skull, and meninges, thus inducing an electrical current in both the central and peripheral nervous systems, which is primarily used in transcranial magnetic stimulation (TMS) for inducing specific effects on different regions or cells that play roles in various brain activities. Studies of repetitive transcranial magnetic stimulation (rTMS) have led to novel attractive therapeutic approaches. Neural stem cells (NSCs) in adult human brain are able to self-renew and possess multidifferential ability to maintain homeostasis and repair damage after acute central nervous system. In the present review, we summarized the electrical activity of NSCs and the fundamental mechanism of electromagnetic fields and their effects on regulating NSC proliferation, differentiation, migration, and maturation. Although it was authorized for the rTMS use in resistant depression patients by US FDA, there are still unveiling mechanism and limitations for rTMS in clinical applications of acute central nervous system injury, especially on NSC regulation as a rehabilitation strategy. More in-depth studies should be performed to provide detailed parameters and mechanisms of rTMS in further studies, making it a powerful tool to treat people who are surviving with acute central nervous system injuries.
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影响因子：
5.3
作者：
Cremisi F
通讯作者：
Cremisi F
影响因子：
5.3
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
5.3
作者：
Feldman, DH;Thinschmidt, JS;Reier, PJ
通讯作者：
Reier, PJ
影响因子：
56.9
作者：
Clarke, DL;Johansson, CB;Frisén, J
通讯作者：
Frisén, J