Inferences on a multidimensional social hierarchy use a grid-like code.

Inferences on a multidimensional social hierarchy use a grid-like code.
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对多维社会等级的推断使用网格状代码。

DOI:
10.1038/s41593-021-00916-3
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发表时间:
2021-09
影响因子:
25
通讯作者:
Boorman ED
Boorman ED
中科院分区:
医学1区
文献类型:
--
作者:
Park SA;Miller DS;Boorman ED

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在新的情况下,总结经验来指导决策是灵活行为的标志。一个环境或任务的认知地图理论上可以提供这种灵活性,但直接的证据已经证明是难以捉摸的。我们发现,离散采样的抽象实体之间的关系,在一个看不见的二维(2-D)的社会层次结构重建成一个单一的2-D认知地图的海马和内嗅皮层。我们进一步表明,人类利用内嗅皮层和内侧前额叶皮层中的网格状代码,在离散决策过程中,在重建的抽象空间中推断实体之间的直接轨迹。内嗅皮层中的这些网格状表示与内侧前额叶皮层和颞顶交界处的决策值计算有关。总的来说,这些发现表明,网格状表示被人类大脑用来推断新的解决方案,即使是在抽象和离散的问题,并提出了一个通用的机制,支持灵活的决策和概括。
Generalizing experiences to guide decision making in novel situations is a hallmark of flexible behavior. Cognitive maps of an environment or task can theoretically afford such flexibility, but direct evidence has proven elusive. We find that discretely sampled abstract relationships between entities in an unseen two-dimensional (2-D) social hierarchy are reconstructed into a unitary 2-D cognitive map in the hippocampus and entorhinal cortex. We further show that humans utilize a grid-like code in entorhinal cortex and medial prefrontal cortex, for inferred direct trajectories between entities in the reconstructed abstract space during discrete decisions. These grid-like representations in the entorhinal cortex are associated with decision value computations in the medial prefrontal cortex and temporoparietal junction. Collectively, these findings show that grid-like representations are used by the human brain to infer novel solutions, even in abstract and discrete problems, and suggest a general mechanism underpinning flexible decision making and generalization.
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