Evaluation of the Microbiome in Men Taking Pre-exposure Prophylaxis for HIV Prevention.
Evaluation of the Microbiome in Men Taking Pre-exposure Prophylaxis for HIV Prevention.
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DOI：
10.1007/s10461-020-03130-7
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发表时间：
2021-07
影响因子：
4.4
通讯作者：
Chan PA
中科院分区：
文献类型：
--
作者：
Perler BK;Reinhart EM;Montgomery M;Maynard M;Shapiro JM;Belenky P;Chan PA
以替诺福韦为基础的方案作为暴露前预防（PrEP）在预防艾滋病毒感染方面非常有效。最常见的副作用是胃肠道（GI）不适，这可能与微生物组的变化有关。微生物组的生态失调可以产生许多与健康相关的后果。为了了解PrEP对生态失调的影响，我们评估了27个人; 14个人平均服用PrEP 171周。使用自行采集的直肠拭子进行16 S rRNA测序。混合β多样性测试表明，使用Bray-Curtis和未加权UniFrac分析的PrEP和非PrEP用户之间存在显著差异（分别为p = 0.05和0.049）。在属水平上，在PrEP使用者中，Finegoldia显著减少，沿着Catenibacterium和Prevotella显著增加。普雷沃菌属与炎症途径、胰岛素抵抗和心血管疾病有关，而链杆菌属与病态肥胖和代谢综合征有关。总的来说，这些结果表明，PrEP可能与某种程度的微生物组生态失调有关，这可能导致GI症状。这些变化的长期影响尚不清楚。
Tenofovir-based regimens as pre-exposure prophylaxis (PrEP) are highly effective at preventing HIV infection. The most common side-effect is gastrointestinal (GI) distress which may be associated with changes in the microbiome. Dysbiosis of the microbiome can have numerous health-related consequences. To understand the effect of PrEP on dysbiosis, we evaluated 27 individuals; 14 were taking PrEP for an average of 171 weeks. Sequencing of 16S rRNA was performed using self-collected rectal swabs. Mixed beta diversity testing demonstrated significant differences between PrEP and non-PrEP users with Bray-Curtis and unweighted UniFrac analyses (p = 0.05 and 0.049, respectively). At the genus level, there was a significant reduction in Finegoldia, along with a significant increase in Catenibacterium and Prevotella in PrEP users. Prevotella has been associated with inflammatory pathways, insulin resistance and cardiovascular disease, while Catenibacterium has been associated with morbid obesity and metabolic syndrome. Overall, these results suggest that PrEP may be associated with some degree of microbiome dysbiosis, which may contribute to GI symptoms. Long-term impact of these changes is unknown.
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影响因子：
3.7
作者：
Price LB;Liu CM;Johnson KE;Aziz M;Lau MK;Bowers J;Ravel J;Keim PS;Serwadda D;Wawer MJ;Gray RH
通讯作者：
Gray RH
影响因子：
4.2
作者：
Fulcher, Jennifer A.;Li, Fan;Aldrovandi, Grace M.
通讯作者：
Aldrovandi, Grace M.
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.6
作者：
Hassan A;Blumenthal JS;Dube MP;Ellorin E;Corado K;Moore DJ;Morris SR
通讯作者：
Morris SR
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP