Molecular epidemiology of eastern equine encephalitis virus, New York.
Molecular epidemiology of eastern equine encephalitis virus, New York.
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DOI：
10.3201/eid1403.070816
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发表时间：
2008-03
影响因子：
11.8
通讯作者：
Ebel GD
中科院分区：
文献类型：
--
作者：
Young DS;Kramer LD;Maffei JG;Dusek RJ;Backenson PB;Mores CN;Bernard KA;Ebel GD
南方菌株正在纽约进行扩增、延续和越冬。东部马脑炎病毒（EEEV）在北部疫源地的延续、越冬和灭绝尚不清楚。因此，我们试图在当前和过去的动物流行病中描述纽约州EEEV的分子流行病学。为了确定EEEV是否越冬，是否定期重新引入，或者两者都有，我们对来自纽约州和美国东海岸的42个EEEV分离株的E2和部分NSP3编码区进行了测序。我们的系统发育分析表明，衍生亚枝倾向于包含在遗传相似的北方菌株之前分离的南方菌株，这表明EEEV沿着东海岸从南向北迁移。2003-2005年和1974-1975年在纽约动物流行病期间分离出的毒株具有很强的聚集性，这表明EEEV在该疫源地越冬。该研究为南方EEEV菌株引入纽约，随后进行本地扩增，延续和越冬提供了分子证据。
Southern strains are undergoing amplification, perpetuation, and overwintering in New York. Perpetuation, overwintering, and extinction of eastern equine encephalitis virus (EEEV) in northern foci are poorly understood. We therefore sought to describe the molecular epidemiology of EEEV in New York State during current and past epizootics. To determine whether EEEV overwinters, is periodically reintroduced, or both, we sequenced the E2 and partial NSP3 coding regions of 42 EEEV isolates from New York State and the Eastern Seaboard of the United States. Our phylogenetic analyses indicated that derived subclades tended to contain southern strains that had been isolated before genetically similar northern strains, suggesting southern to northern migration of EEEV along the Eastern Seaboard. Strong clustering among strains isolated during epizootics in New York from 2003–2005, as well as from 1974–1975, demonstrates that EEEV has overwintered in this focus. This study provides molecular evidence for the introduction of southern EEEV strains to New York, followed by local amplification, perpetuation, and overwintering.
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影响因子：
9.4
作者：
Lambert, AJ;Martin, DA;Lanciotti, RS
通讯作者：
Lanciotti, RS
DOI：
10.4269/ajtmh.1999.61.579
发表时间：
1999-10-01
影响因子：
3.3
作者：
Brault, AC;Powers, AM;Weaver, SC
通讯作者：
Weaver, SC
影响因子：
9.4
作者：
Garmendia, AE;Van Kruiningen, HJ;West, AB
通讯作者：
West, AB
影响因子：
3.8
作者：
Jerzak, G;Bernard, KA;Ebel, GD
通讯作者：
Ebel, GD
影响因子：
3.7
作者：
Bernard, KA;Klimstra, WB;Johnston, RE
通讯作者：
Johnston, RE