Chitin synthesis and fungal pathogenesis.

Chitin synthesis and fungal pathogenesis.
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DOI:
10.1016/j.mib.2010.05.002
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发表时间:
2010-08
影响因子:
5.4
通讯作者:
Gow, Neil A. R.
Gow, Neil A. R.
中科院分区:
生物学2区
文献类型:
--
作者:
Lenardon, Megan D.;Munro, Carol A.;Gow, Neil A. R.

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几丁质是真菌细胞壁碳水化合物骨架的重要组成部分,是一种在人类和其他脊椎动物中没有的分子。复杂的调控机制使几丁质能够定位于整个细胞周期的特定位点,以维持细胞壁的整体强度,并在细胞壁应力条件下实现快速、挽救生命的修饰。几丁质最近也在真菌和其他含几丁质寄生虫的免疫反应的激活和衰减中发挥了重要作用。本文综述了几丁质合成调控在真菌发病机制研究中的最新进展。
Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis.
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