Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA.
Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA.
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sIgM 交联激活 B 细胞会诱导 CD5 mRNA 的积累。
DOI：
10.1007/978-3-642-79275-5_26
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发表时间：
1995
影响因子：
--
通讯作者：
Wortis,HH
中科院分区：
文献类型：
--
作者：
Bandyopadhyay,RS;Teutsch,MR;Wortis,HH
The surface membrane molecule CD5 is expressed on mature T cells and on the B-la subpopulation of B cells. These CD5 positive B cells express an antibody repertoire with a relatively high frequency of self-reactivity. There is uncertainty about the origins of CD5 B cells and the reasons for this are reviewed. Recent reports which relate to the lineage/selection debate are discussed. For instance, an increase in the frequency of CD5 B cells is a feature of several genetically determined polysystem autoimmune syndromes. In the case ofmotheaten(me, mev) the pathogenesis of this increase in CD5 B cells is not yet understood, even though the mutation has been mapped to theHematopoietic cell protein-tyrosine phosphatase (Hcph)gene. Another mutation which affects B cell development, X-linked immunodeficiency (xid), encodes a point mutation in a B cell cytoplasmic tyrosine kinase. Expression of xid in otherwise normal mice causes a lack of CD5 B cells and a shift in the antibody repertoire. Interestingly, expression of bothxidandmotheatenresults in an amelioration of autoantibody production. Evidence is presented that in B cells regulation of expression of CD5 can occur at the level of mRNA and that cross-linking of slgM can induce the accumulation of CD5 mRNA. The overall concept advanced is that cells expressing natural autoantibodies are triggered via slgM ligation to become CD5 B cells.
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