Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder.
Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder.
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DOI：
10.1038/bjc.1994.376
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发表时间：
1994-10
影响因子：
8.8
通讯作者：
Brown, K. W.
中科院分区：
文献类型：
--
作者：
Brewster, S. F.;Gingell, J. C.;Browne, S.;Brown, K. W.
体细胞等位基因丢失被认为是肿瘤抑制基因失活的标志。对31例人膀胱移行细胞癌（tcc）患者进行了5个染色体18q位点的等位基因缺失检测，其中包括DCC基因（在结直肠癌中缺失）和染色体11p15位点的限制性片段长度多态性分析。在9/26（35%）的样本中观察到一个或多个18q位点的等位基因缺失，与肌肉侵袭性疾病相关（P < 0.02）。在8/24（33%）的样本中，DCC处观察到等位基因丢失，与肌肉侵袭性疾病相关（P = 0.05）。5例可评估的复发性tcc中有3例在DCC处表现出等位基因缺失，其中2例是浅表性的。在保留两个DCC等位基因的肿瘤中，没有检测到其他18q位点的等位基因丢失。在5/20（25%）的肿瘤中观察到11p15位点的等位基因丢失。这些数据提示在TCC膀胱癌中存在位于18q的晚作用TSG。DCC是一个候选基因，因为它位于最常见的缺失区域（18q21.3-qter）。
Somatic allelic loss is regarded as a hallmark of tumour-suppressor gene (TSG) inactivation. Thirty-one human bladder transitional cell carcinomas (TCCs) were examined for allelic loss at five chromosome 18q loci, including the DCC gene (deleted in colorectal carcinoma) and at chromosome 11p15 in a restriction fragment length polymorphism analysis. Allelic loss was observed at one or more 18q loci in 9/26 (35%) samples, associated with muscle-invasive disease (P < 0.02). Allelic loss was observed at DCC in 8/24 (33%) samples, associated with muscle-invasive disease (P = 0.05). Three out of the five evaluable recurrent TCCs exhibited allelic loss at DCC, two of which were superficial. No allelic losses were detected at other 18q loci in tumours which retained both DCC alleles. Allelic loss was observed at 11p15 in 5/20 (25%) tumours. These data suggest the presence of a late-acting TSG located on 18q in TCC bladder cancer. DCC is a candidate gene since it lies within the region of most common deletion (18q21.3-qter).
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