Spatial distribution of hand-grasp motor task activity in spinal cord functional magnetic resonance imaging.
Spatial distribution of hand-grasp motor task activity in spinal cord functional magnetic resonance imaging.
复制标题
脊髓功能磁共振成像中手部抓握运动任务活动的空间分布。
DOI：
10.1002/hbm.26458
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发表时间：
2023-12-01
影响因子：
4.8
通讯作者：
Bright, Molly G.
中科院分区：
文献类型：
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作者：
Hemmerling, Kimberly J.;Hoggarth, Mark A.;Sandhu, Milap S.;Parrish, Todd B.;Bright, Molly G.
关键词：
脊髓功能磁共振成像 (fMRI) 期间的上肢运动范式可以深入了解脊髓的功能组织。抓握是一项具有临床意义的重要日常功能，但之前对类似挤压动作的研究并未报告一致的活动区域，并且受到样本量和简单化分析方法的限制。在这里，我们使用单手等长抓握任务来研究脊髓功能磁共振成像激活，该任务根据参与者最大随意收缩（MVC）进行校准。考虑了两种任务建模方法：(1) 从理想化块设计 (Ideal) 派生的任务回归器和 (2) 基于标准化为单个 MVC (%MVC) 的记录力轨迹的任务回归器。在这两种方法中，群体运动活动高度偏向于任务一侧的同侧半索。激活跨越 C5-C8，主要位于 C7 脊髓段。还观察到空间分布的具体差异，例如使用 %MVC 回归器时 C8 和背索活动的增加。此外，我们探讨了数据量和空间平滑对手握运动任务激活敏感性的影响。该分析显示，与功能磁共振成像运行次数、样本大小和空间平滑相关的活动体素数量大幅增加，证明了实验设计选择对运动激活的影响。使用理想化的块设计和标准化为参与者最大自主收缩的力轨迹，通过脊髓功能磁共振成像来绘制手部抓握运动任务激活图。任务激活偏向于任务侧同侧的半索，并且主要定位于 C7 脊髓段。
Upper extremity motor paradigms during spinal cord functional magnetic resonance imaging (fMRI) can provide insight into the functional organization of the cord. Hand‐grasping is an important daily function with clinical significance, but previous studies of similar squeezing movements have not reported consistent areas of activity and are limited by sample size and simplistic analysis methods. Here, we study spinal cord fMRI activation using a unimanual isometric hand‐grasping task that is calibrated to participant maximum voluntary contraction (MVC). Two task modeling methods were considered: (1) a task regressor derived from an idealized block design (Ideal) and (2) a task regressor based on the recorded force trace normalized to individual MVC (%MVC). Across these two methods, group motor activity was highly lateralized to the hemicord ipsilateral to the side of the task. Activation spanned C5–C8 and was primarily localized to the C7 spinal cord segment. Specific differences in spatial distribution are also observed, such as an increase in C8 and dorsal cord activity when using the %MVC regressor. Furthermore, we explored the impact of data quantity and spatial smoothing on sensitivity to hand‐grasp motor task activation. This analysis shows a large increase in number of active voxels associated with the number of fMRI runs, sample size, and spatial smoothing, demonstrating the impact of experimental design choices on motor activation. Hand‐grasping motor task activation was mapped with spinal cord functional magnetic resonance imaging using an idealized block design and a force trace normalized to participant maximum voluntary contraction. Task activation was lateralized to the hemicord ipsilateral to the task side and primarily localized to the C7 spinal cord segment.
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影响因子：
3.3
作者：
Barry RL;Conrad BN;Maki S;Watchmaker JM;McKeithan LJ;Box BA;Weinberg QR;Smith SA;Gore JC
通讯作者：
Gore JC
影响因子：
3.3
作者：
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通讯作者：
Wehrli, Felix W.
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通讯作者：
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