Multi-shot acquisitions for stimulus-evoked spinal cord BOLD fMRI.
Multi-shot acquisitions for stimulus-evoked spinal cord BOLD fMRI.
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DOI：
10.1002/mrm.28570
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发表时间：
2021-04
影响因子：
3.3
通讯作者：
Gore JC
中科院分区：
文献类型：
--
作者：
Barry RL;Conrad BN;Maki S;Watchmaker JM;McKeithan LJ;Box BA;Weinberg QR;Smith SA;Gore JC
证明三维多激发磁共振成像采集在人体脊髓中刺激诱发血氧水平依赖（BOLD）功能磁共振成像（fMRI）的可行性。在3特斯拉下进行了两项fMRI研究。第一项研究是高碳酸气体挑战，其中使用多次激发3D快速场回波（FFE）序列以及单次激发多切片回波平面成像（EPI）从健康志愿者中采集数据。在第二项研究中，另一组健康志愿者进行上肢运动任务，同时使用3D多激发采集功能磁共振成像数据。2D-EPI和3D-FFE均对颈髓中的BOLD信号变化敏感，并且在灰质中具有可比的对比噪声比。与EPI相比，FFE表现出更少的信号丢失和更弱的几何失真。在运动范式研究中，活动体素的平均数量是最高的腹侧灰质角同侧的一侧的任务，并在脊髓水平与神经支配的手指伸肌。高度多激发采集序列（如3D-FFE）非常适合刺激诱发的脊髓BOLD fMRI。
To demonstrate the feasibility of 3D multi-shot magnetic resonance imaging acquisitions for stimulus-evoked blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) in the human spinal cord in vivo. Two fMRI studies were performed at 3 Tesla. The first study was a hypercapnic gas challenge where data were acquired from healthy volunteers using a multi-shot 3D fast field echo (FFE) sequence as well as single-shot multi-slice echo-planar imaging (EPI). In the second study, another cohort of healthy volunteers performed an upper extremity motor task while fMRI data were acquired using a 3D multi-shot acquisition. Both 2D-EPI and 3D-FFE were shown to be sensitive to BOLD signal changes in the cervical spinal cord, and had comparable contrast-to-noise ratios in gray matter. FFE exhibited much less signal drop-out and weaker geometric distortions compared to EPI. In the motor paradigm study, the mean number of active voxels was highest in the ventral gray matter horns ipsilateral to the side of the task and at the spinal level associated with innervation of finger extensors. Highly multi-shot acquisition sequences such as 3D-FFE are well suited for stimulus-evoked spinal cord BOLD fMRI.
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