Ultrawide Field Imaging in Diabetic Retinopathy: Exploring the Role of Quantitative Metrics.
Ultrawide Field Imaging in Diabetic Retinopathy: Exploring the Role of Quantitative Metrics.
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DOI：
10.3390/jcm10153300
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发表时间：
2021-07-27
影响因子：
3.9
通讯作者：
Aiello LP
中科院分区：
文献类型：
--
作者：
Ashraf M;Cavallerano JD;Sun JK;Silva PS;Aiello LP
超宽视野成像(UWF)可以显示比以前标准方法明显更大的视网膜区域。在糖尿病视网膜病变(DR)中，与七种标准ETDRS视野相比，UWF成像上可以看到明显更多的病变。此外，一些眼睛的病变主要位于外围视网膜，这与DR进展的风险增加有关。目前的DR严重程度评分仍然主要基于临床可见的视网膜微血管病变，没有包括视网膜周围、神经视网膜或病理生理变化。因此，目前的量表不适合记录早期或晚期糖尿病视网膜病变的进展或退化，也不适用于血管内皮生长因子抑制剂(抗血管内皮生长因子)的治疗。此外，分类系统的主观性很强，不同的评分者根据经验水平和培训背景进行评分是不同的。最近，人们一直在努力在UWF成像上对DR损害进行量化，试图为分类、疾病预测和治疗反应预测产生客观的指标。这篇综述的目的是检查目前来自UWF荧光素血管造影和UWF彩色成像的定量指标，以确定它们在未来任何可能的DR分类中的可行性。
Ultrawide field imaging (UWF) has allowed the visualization of a significantly greater area of the retina than previous standard approaches. In diabetic retinopathy (DR), significantly more lesions are seen on UWF imaging compared to the seven-standard ETDRS fields. In addition, some eyes have lesions that are located predominantly in the peripheral retina that are associated with an increased risk of DR progression. The current DR severity scales are still largely based on clinically visible retinal microvascular lesions and do not incorporate retinal periphery, neuroretinal, or pathophysiologic changes. Thus, current scales are not well suited for documenting progression or regression in eyes with very early or advanced DR, nor in the setting of vascular endothelial growth factor inhibitors (antiVEGF). In addition, the categorical system is highly subjective, and grading is variable between different graders based on experience level and training background. Recently, there have been efforts to quantify DR lesions on UWF imaging in an attempt to generate objective metrics for classification, disease prognostication and prediction of treatment response. The purpose of this review is to examine current quantitative metrics derived from UWF fluorescein angiograms and UWF color imaging to determine their feasibility in any potential future DR classification.
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DOI：
10.1097/iae.0000000000002579
发表时间：
2020-06-01
影响因子：
3.3
作者：
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通讯作者：
Ip, Michael
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
4.2
作者：
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影响因子：
13.7
作者：
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通讯作者：
Tadayoni, Ramin
影响因子：
4.4
作者：
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Huang D