Vagus nerve stimulation delivered during motor rehabilitation improves recovery in a rat model of stroke.
Vagus nerve stimulation delivered during motor rehabilitation improves recovery in a rat model of stroke.
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DOI：
10.1177/1545968314521006
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发表时间：
2014-09
影响因子：
4.2
通讯作者：
Kilgard MP
中科院分区：
文献类型：
--
作者：
Khodaparast N;Hays SA;Sloan AM;Fayyaz T;Hulsey DR;Rennaker RL 2nd;Kilgard MP
人们普遍认为神经可塑性有助于脑损伤后的功能恢复。迷走神经刺激与不同的前肢运动相结合，会导致大鼠初级运动皮层产生持久的地图可塑性，这是配对运动所特有的。我们测试了这样的假设：反复将迷走神经刺激与上前肢运动配对可以改善中风大鼠模型运动功能的恢复。大鼠被分为三组：康复期间迷走神经刺激、康复后迷走神经刺激和单独康复。动物经历4个训练阶段：塑造（运动技能学习）、病变前训练、病变后训练和治疗训练。大鼠运动皮层内出现单侧缺血性病变，并植入左迷走神经套。在损伤后基线训练之前允许动物恢复一周。在治疗训练阶段，大鼠接受与每次成功试验配对的迷走神经刺激。在执行运动迟缓评估任务时，所有十七只经过训练的大鼠均表现出明显的对侧前肢损伤。在康复训练期间进行迷走神经刺激时，前肢功能完全恢复到病变前的水平。或者，单独进行强化康复训练（无刺激）无法将功能恢复到病变前的水平。与单独的康复训练相比，在康复训练后提供相同量的刺激并没有带来改善。这些结果表明，重复迷走神经刺激与成功的前肢运动相结合可以改善运动皮层缺血后的恢复，并且可能是中风康复的可行选择。
Neural plasticity is widely believed to support functional recovery following brain damage. Vagus nerve stimulation paired with different forelimb movements causes long-lasting map plasticity in rat primary motor cortex that is specific to the paired movement. We tested the hypothesis that repeatedly pairing vagus nerve stimulation with upper forelimb movements would improve recovery of motor function in a rat model of stroke. Rats were separated into three groups: vagus nerve stimulation during rehab, vagus nerve stimulation after rehab, and rehab alone. Animals underwent 4 training stages: shaping (motor skill learning), pre-lesion training, post-lesion training, and therapeutic training. Rats were given a unilateral ischemic lesion within motor cortex and implanted with a left vagus nerve cuff. Animals were allowed one week of recovery before post-lesion baseline training. During the therapeutic training stage, rats received vagus nerve stimulation paired with each successful trial. All seventeen trained rats demonstrated significant contralateral forelimb impairment when performing a bradykinesia assessment task. Forelimb function was recovered completely to pre-lesion levels when vagus nerve stimulation was delivered during rehab training. Alternatively, intensive rehab training alone (without stimulation) failed to restore function to pre-lesion levels. Delivering the same amount of stimulation after rehab training did not yield improvements compared to rehab alone. These results demonstrate that vagus nerve stimulation repeatedly paired with successful forelimb movements can improve recovery after motor cortex ischemia and may be a viable option for stroke rehabilitation.
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影响因子：
2.7
作者：
Gilmour, G;Iverson, SD;Bannerman, DM
通讯作者：
Bannerman, DM
影响因子：
2.9
作者：
Leary, MC;Saver, JL
通讯作者：
Saver, JL
影响因子：
5.3
作者：
Sjögren, MJC;Hellström, PTO;Ben-Menachem, E
通讯作者：
Ben-Menachem, E
影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
4.8
作者：
Krakauer, JW
通讯作者：
Krakauer, JW