The Role of Lung Resident Mesenchymal Stromal Cells in the Pathogenesis and Repair of Chronic Lung Disease.
The Role of Lung Resident Mesenchymal Stromal Cells in the Pathogenesis and Repair of Chronic Lung Disease.
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DOI：
10.1093/stmcls/sxad014
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发表时间：
2023-05-15
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影响因子：
--
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间充质基质/干细胞是多能成体细胞，可以从包括肺在内的许多组织中提取。肺驻留MSC（LR-MSC）定位于血管周围空间，在那里它们充当肺稳态的重要调节剂，介导肺损伤/损伤与修复过程之间的平衡。LR-MSC通过调节免疫应答和释放营养因子来支持肺组织的完整性。然而，在慢性肺部疾病的情况下，LR-MSC维持肺内稳态和促进修复的能力减弱。在这种情况下，LR-MSC可以通过其改变的分泌和免疫调节特性来促进疾病的发病机制。此外，它们能够分化成肌成纤维细胞，从而促成许多肺部疾病的纤维化方面。例如，在特发性肺纤维化中，多种因子可以刺激它们分化成肌成纤维细胞，包括肿瘤坏死因子-α（TNF-α）、转化生长因子-β1（TGF-β1）、内质网（ER）应激、Hedgehog（HH）和无翼/整合（Wnt）信号传导。在这里，我们回顾了目前的文献LR-MSCs的特点，并描述了他们在肺内稳态/修复和慢性肺部疾病的发病机制中的作用。
Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to perivascular spaces where they act as important regulators of pulmonary homeostasis, mediating the balance between lung injury/damage and repair processes. LR-MSCs support the integrity of the lung tissue via modulation of the immune response and release of trophic factors. However, in the context of chronic lung diseases, the ability of LR-MSCs to maintain pulmonary homeostasis and facilitate repair is diminished. In this setting, LR-MSC can contribute to the pathogenesis of disease, through their altered secretory and immunomodulatory properties. In addition, they are capable of differentiating into myofibroblasts, thereby contributing to the fibrotic aspects of numerous lung diseases. For example, in idiopathic pulmonary fibrosis, a variety of factors can stimulate their differentiation into myofibroblasts including tumor necrosis factor-α (TNF-(α), transforming growth factor-β1 (TGF-β1), endoplasmic reticulum (ER) stress, Hedgehog (HH), and Wingless/integrated (Wnt) signaling. Here, we review the current literature on the characterization of LR-MSCs and describe their roles in pulmonary homeostasis/repair and in the pathogenesis of chronic lung disease.
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影响因子：
5.2
作者：
Badri, Linda;Lama, Vibha N.
通讯作者：
Lama, Vibha N.
DOI：
10.1165/rcmb.2018-0351oc
发表时间：
2019-11-01
影响因子：
6.4
作者：
Cruz, Tamara;Lopez-Giraldo, Alejandra;Faner, Rosa
通讯作者：
Faner, Rosa
DOI：
10.1111/j.1365-2184.1970.tb00347.x
发表时间：
1970-01-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
FRIEDENSTEIN, AJ;CHAILAKHJAN, RK;LALYKINA, KS
通讯作者：
LALYKINA, KS
影响因子：
4
作者：
Collins, Jennifer J. P.;Lithopoulos, Marissa A.;Thebaud, Bernard
通讯作者：
Thebaud, Bernard
影响因子：
20.3
作者：
Aggarwal, S;Pittenger, MF
通讯作者：
Pittenger, MF