7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls.
7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls.
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DOI：
10.1002/jmri.24683
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发表时间：
2015-05
影响因子：
4.4
通讯作者：
Regatte, Ravinder R.
中科院分区：
文献类型：
--
作者：
Chang, Gregory;Xia, Ding;Chen, Cheng;Madelin, Guillaume;Abramson, Steven B.;Babb, James S.;Saha, Punam K.;Regatte, Ravinder R.
To determine how subchondral bone microarchitecture is altered in patients with mild knee osteoarthritis. This study had Institutional Review Board approval. We recruited 24 subjects with mild radiographic knee osteoarthritis and 16 healthy controls. The distal femur was scanned at 7T using a high-resolution 3D FLASH sequence. We applied digital topological analysis to assess bone volume fraction, markers of trabecular number (skeleton density), trabecular network osteoclastic resorption (erosion index), plate-like structure (surface), rod-like structure (curve), and plate-to-rod ratio (surface-curve ratio). We used two-tailed t-tests to compare differences between osteoarthritis subjects and controls. 7T magnetic resonance imaging (MRI) detected deterioration in subchondral bone microarchitecture in both medial and lateral femoral condyles in osteoarthritis subjects as compared with controls. This was manifested by lower bone volume fraction (−1.03% to −5.43%, P<0.04), higher erosion index (+8.49 to +22.76%, P<0.04), lower surface number (−2.31% to −9.63%, P<0.007), higher curve number (+6.85% to +16.93%, P<0.03), and lower plate-to-rod ratio (−7.92% to −21.71%, P<0.05). The results provide further support for the concept that poor subchondral bone quality is associated with osteoarthritis and may serve as a potential therapeutic target for osteoarthritis interventions.
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影响因子：
4.9
作者：
Spector, Tim D;Conaghan, Philip G;Buckland-Wright, J Christopher;Garnero, Patrick;Cline, Gary A;Beary, John F;Valent, David J;Meyer, Joan M
通讯作者：
Meyer, Joan M
影响因子：
19.7
作者：
Madelin, Guillaume;Babb, James;Regatte, Ravinder R.
通讯作者：
Regatte, Ravinder R.
影响因子：
7
作者：
Mohan, G.;Perilli, E.;Kuliwaba, J. S.
通讯作者：
Kuliwaba, J. S.
影响因子：
4.5
作者：
Saha, PK;Chaudhuri, BB
通讯作者：
Chaudhuri, BB
影响因子：
7
作者：
Lindsey, CT;Narasimhan, A;Majumdar, S
通讯作者：
Majumdar, S