Brain-Computer Interface Training after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers.
Brain-Computer Interface Training after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers.
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DOI：
10.3389/fnhum.2016.00457
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发表时间：
2016
影响因子：
2.9
通讯作者：
Prabhakaran V
中科院分区：
文献类型：
--
作者：
Young BM;Stamm JM;Song J;Remsik AB;Nair VA;Tyler ME;Edwards DF;Caldera K;Sattin JA;Williams JC;Prabhakaran V
背景：脑机接口（BCI）设备正在研究其在中风康复中的应用，但人们对运动系统的结构变化与使用这些系统的行为测量之间的关系知之甚少。目的：本研究探讨了弥散张量成像 (DTI) 衍生指标与接受或未接受 BCI 训练的中风患者行为变化之间的关系。方法：使用中风影响量表（SIS）、行动研究手臂测试（ARAT）、九孔钉测试（9-HPT）和DTI扫描对患有上肢运动障碍的中风患者（n = 19）进行评估。十名受试者在控制期内完成了四次评估，在此期间没有进行任何培训。 17 名受试者（包括 8 名完成对照期的受试者）在实验期内完成了四项评估，在此期间受试者接受了介入性 BCI 培训。每次扫描时，从每个皮质脊髓束 (CST) 和经胼胝体运动纤维中提取分数各向异性 (FA) 值。结果：在 DTI 或行为测量中，在组水平上没有发现显着的按时间分组的交互作用。在控制期间，对侧 CST FA 和不对称 FA (aFA) 的增加与 SIS 和 9-HPT 得分较差相关。在实验期间（BCI 训练），对侧 CST FA 的增加与 9-HPT 的改善相关，而 aFA 的增加与 ARAT 的改善相关，但与 9-HPT 表现恶化相关；经胼胝体运动纤维的变化与对侧 CST 的变化呈正相关。所有相关性 p < 0.05 均已校正。结论：这些研究结果表明，对侧 CST 的完整性可用于跟踪中风后通过 BCI 训练观察到的个体行为变化。
Background: Brain–computer interface (BCI) devices are being investigated for their application in stroke rehabilitation, but little is known about how structural changes in the motor system relate to behavioral measures with the use of these systems. Objective: This study examined relationships among diffusion tensor imaging (DTI)-derived metrics and with behavioral changes in stroke patients with and without BCI training. Methods: Stroke patients (n = 19) with upper extremity motor impairment were assessed using Stroke Impact Scale (SIS), Action Research Arm Test (ARAT), Nine-Hole Peg Test (9-HPT), and DTI scans. Ten subjects completed four assessments over a control period during which no training was administered. Seventeen subjects, including eight who completed the control period, completed four assessments over an experimental period during which subjects received interventional BCI training. Fractional anisotropy (FA) values were extracted from each corticospinal tract (CST) and transcallosal motor fibers for each scan. Results: No significant group by time interactions were identified at the group level in DTI or behavioral measures. During the control period, increases in contralesional CST FA and in asymmetric FA (aFA) correlated with poorer scores on SIS and 9-HPT. During the experimental period (with BCI training), increases in contralesional CST FA were correlated with improvements in 9-HPT while increases in aFA correlated with improvements in ARAT but with worsening 9-HPT performance; changes in transcallosal motor fibers positively correlated with those in the contralesional CST. All correlations p < 0.05 corrected. Conclusion: These findings suggest that the integrity of the contralesional CST may be used to track individual behavioral changes observed with BCI training after stroke.
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DOI：
10.3389/fneng.2014.00030
发表时间：
2014
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Ang KK;Guan C;Phua KS;Wang C;Zhou L;Tang KY;Ephraim Joseph GJ;Kuah CW;Chua KS
通讯作者：
Chua KS
影响因子：
2.9
作者：
Kwon HG;Son SM;Jang SH
通讯作者：
Jang SH
影响因子：
3.7
作者：
Li Y;Wu P;Liang F;Huang W
通讯作者：
Huang W
影响因子：
8.3
作者：
Liu Z;Li Y;Zhang X;Savant-Bhonsale S;Chopp M
通讯作者：
Chopp M
影响因子：
9.5
作者：
Ballinger, GA
通讯作者：
Ballinger, GA