Development of the transcallosal motor fiber from the corticospinal tract in the human brain: diffusion tensor imaging study.
Development of the transcallosal motor fiber from the corticospinal tract in the human brain: diffusion tensor imaging study.
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DOI：
10.3389/fnhum.2014.00153
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发表时间：
2014
影响因子：
2.9
通讯作者：
Jang SH
中科院分区：
文献类型：
--
作者：
Kwon HG;Son SM;Jang SH
胼胝体运动纤维（TCMF）在两个初级运动皮层之间的半球间抑制（IHI）中起作用。IHI是脑运动系统发育的一个重要概念。许多研究都集中在对TCMF形貌的研究上，但对TCMF的发展却知之甚少。在本研究中，我们试图研究的发展TCMF从皮质脊髓束（CST）在人脑中使用扩散张量纤维束成像。本研究共招募了76例健康受试者。我们重建TCMF，这是来自CST，通过选择胼胝体（上，中脑桥）以下的两个感兴趣的区域。用于纤维追踪的终止标准是分数各向异性<0.2和<45 °、60 °和75°的三个道转向角。根据年龄将受试者分为四组：A组（0-5岁）、B组（6-10岁）、C组（11-15岁）和D组（16-20岁）。B组与C组、B组与D组比较，TCMF发生率差异有统计学意义（p < 0.05）。而C组和D组在各径路转角方面均无显著性差异（p > 0.05）。此外，在TCMF的发生率方面，三个束转向角之间没有观察到显著差异（p > 0.05）。我们获得了可视化的TCMF从CST与发展，发现TCMF的发病率有显着差异，大约在10岁左右。因此，我们证明了TCMF在人脑中发展的结构证据。
Transcallosal motor fiber (TCMF) plays a role in interhemispheric inhibition (IHI) between two primary motor cortices. IHI has been an important concept in development of the motor system of the brain. Many studies have focused on the research of the topography of TCMF, however, little is known about development of TCMF. In the current study, we attempted to investigate development of TCMF from the corticospinal tract (CST) in the human brain using diffusion tensor tractography. A total of 76 healthy subjects were recruited for this study. We reconstructed the TCMF, which was derived from the CST, by selection of two regions of interest below the corpus callosum (upper and middle pons). Termination criteria used for fiber tracking were fractional anisotropy <0.2 and three tract turning angles of <45, 60, and 75°. The subjects were classified into four groups according to age: group A (0–5 years), group B (6–10 years), group C (11–15 years), and group D (16–20 years). Significant differences in the incidence of TCMF were observed between group B and group C, and between group B and group D, with tract turning angles of 60 and 75° (p < 0.05). However, no significant differences in any tract turning angle were observed between group C and group D (p > 0.05). In addition, in terms of the incidence of TCMF, no significant differences were observed between the three tract turning angles (p > 0.05). We obtained visualized TCMF from the CST with development and found that the incidence of TCMF differed significantly around the approximate age of 10 years. As a result, we demonstrated structural evidence for development of TCMF in the human brain.
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影响因子：
6.7
作者：
Koerte, Inga;Heinen, Florian;Ertl-Wagner, Birgit
通讯作者：
Ertl-Wagner, Birgit
DOI：
10.1098/rstb.2005.1639
发表时间：
2005-05-29
影响因子：
6.3
作者：
Parker, GJM;Alexander, DC
通讯作者：
Alexander, DC
DOI：
10.1111/j.1469-8749.2010.03766.x
发表时间：
2010-12-01
影响因子：
3.8
作者：
Koerte, Inga;Eftimov, Lara;Danek, Adrian
通讯作者：
Danek, Adrian
影响因子：
5.1
作者：
COHEN, HJ;TAFT, LT;BIRCH, HG
通讯作者：
BIRCH, HG
影响因子：
6.1
作者：
Jang, Sung Ho
通讯作者：
Jang, Sung Ho