Evidence of leaky protection following COVID-19 vaccination and SARS-CoV-2 infection in an incarcerated population.
Evidence of leaky protection following COVID-19 vaccination and SARS-CoV-2 infection in an incarcerated population.
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DOI：
10.1038/s41467-023-40750-8
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发表时间：
2023-08-19
影响因子：
16.6
通讯作者：
Ko, Albert I.
中科院分区：
文献类型：
--
作者：
Lind, Margaret L.;Dorion, Murilo;Houde, Amy J.;Lansing, Mary;Lapidus, Sarah;Thomas, Russell;Yildirim, Inci;Omer, Saad B.;Schulz, Wade L.;Andrews, Jason R.;Hitchings, Matt D. T.;Kennedy, Byron S.;Richeson, Robert P.;Cummings, Derek A. T.;Ko, Albert I.
目前尚不清楚SARS-CoV-2感染和新冠肺炎疫苗是否提供了暴露依赖(“泄漏”)的感染保护。我们研究了先前感染、接种疫苗和混合免疫对康涅狄格州惩教机构居民在奥米克龙和德尔塔病毒主要传播期间感染风险的影响。与感染SARS-CoV-2的居民的设施和日期相匹配。在Omicron期间，先前感染、接种疫苗和混合免疫降低了无记录暴露(HR：0.36[0.25-0.54]；0.57[0.42-0.78]；0.24[0.15-0.39])和有细胞块暴露(0.61[0.49-0.75]；0.69[0.58-0.83]；0.41[0.31-0.55]；分别为0.89[0.58-1.35]；0.96[0.64-1.46]；0.80[0.46-1.39]；在三角洲时期，当分析仅限于被测试的居民时，关联是相似的。尽管由于数据集的限制，相关性可能没有得到彻底调整，但研究结果表明，先前的感染和疫苗接种可能是泄漏的，这突显了在拥挤的环境中将疫苗接种与非药物干预措施配对的潜在好处。衡量一个人接触新冠肺炎的水平是具有挑战性的，因此还不清楚高接触是否会影响免疫力。在这里，作者使用来自美国康涅狄格州一家惩教机构的数据，通过比较共享细胞、细胞块和没有已知暴露的人的感染率来研究这个问题。
Whether SARS-CoV-2 infection and COVID-19 vaccines confer exposure-dependent (“leaky”) protection against infection remains unknown. We examined the effect of prior infection, vaccination, and hybrid immunity on infection risk among residents of Connecticut correctional facilities during periods of predominant Omicron and Delta transmission. Residents with cell, cellblock, and no documented exposure to SARS-CoV-2 infected residents were matched by facility and date. During the Omicron period, prior infection, vaccination, and hybrid immunity reduced the infection risk of residents without a documented exposure (HR: 0.36 [0.25–0.54]; 0.57 [0.42–0.78]; 0.24 [0.15–0.39]; respectively) and with cellblock exposures (0.61 [0.49–0.75]; 0.69 [0.58–0.83]; 0.41 [0.31–0.55]; respectively) but not with cell exposures (0.89 [0.58–1.35]; 0.96 [0.64–1.46]; 0.80 [0.46–1.39]; respectively). Associations were similar during the Delta period and when analyses were restricted to tested residents. Although associations may not have been thoroughly adjusted due to dataset limitations, the findings suggest that prior infection and vaccination may be leaky, highlighting the potential benefits of pairing vaccination with non-pharmaceutical interventions in crowded settings. Measuring an individual’s level of exposure to COVID-19 is challenging, and it is therefore unclear whether high exposure may impact immunity. Here, the authors investigate this question using data from a correctional facility in Connecticut, USA, by comparing rates of infection in people who share cells, cellblocks, and with no known exposure.
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既往 SARS-CoV-2 感染和混合免疫对 omicron 变异和严重疾病的保护有效性：系统评价和荟萃回归。
影响因子：
56.3
作者：
Bobrovitz, Niklas;Ware, Harriet;Ma, Xiaomeng;Li, Zihan;Hosseini, Reza;Cao, Christian;Selemon, Anabel;Whelan, Mairead;Premji, Zahra;Issa, Hanane;Cheng, Brianna;Abu Raddad, Laith J.;Buckeridge, David L.;Van Kerkhove, Maria D.;Piechotta, Vanessa;Higdon, Melissa M.;Wilder-Smith, Annelies;Bergeri, Isabel;Feikin, Daniel R.;Arora, Rahul K.;Patel, Minal K.;Subissi, Lorenzo
通讯作者：
Subissi, Lorenzo
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
DOI：
10.1126/science.abq0203
发表时间：
2022-08-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
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影响因子：
6.4
作者：
Grewal, Ramandip;Nguyen, Lena;Kwong, Jeffrey C.
通讯作者：
Kwong, Jeffrey C.
影响因子：
5
作者：
Kahn, Rebecca;Schrag, Stephanie J.;Lipsitch, Marc
通讯作者：
Lipsitch, Marc