Potential of the bioflavonoids in the prevention/treatment of ocular disorders.
Potential of the bioflavonoids in the prevention/treatment of ocular disorders.
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DOI：
10.1211/jpp.62.08.0001
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Srirangam R
中科院分区：
文献类型：
--
作者：
Majumdar S;Srirangam R
黄酮类化合物是一种常见的植物多酚类化合物，它们赋予水果和蔬菜以颜色和味道。近年来，黄酮类化合物通过其对人类健康的有益作用在制药领域获得了重要性，并作为营养补充剂被广泛使用。该生物素的几种药理活性可用于预防或治疗导致视力丧失的眼部疾病，如糖尿病性视网膜病变、黄斑变性和白内障。本文综述了各种生物素在不同眼部疾病中的潜在治疗应用，并讨论了这些药物向眼组织的递送。显然，类黄酮能够作用于导致不同视力威胁性眼病发展的各种机制或病因学因素。从药物递送的角度来看，眼部生物利用度取决于所选黄酮类化合物的理化和生物药学特征，并且非常重要的是给药途径。本文综述了各种生物素在眼部疾病中的潜在治疗应用，并讨论了这些药物向眼组织的递送。虽然口服给药的双氯芬酸可能在眼后段的外部表现出一定的药理活性，但体内视网膜神经节细胞的保护可能受到这种给药途径的限制。这些药物的全身或局部给药可能在眼组织中产生更高和有效的母体生物素浓度，并且剂量要低得多。
Flavonoids are a common group of plant polyphenols that give color and flavor to fruits and vegetables. In recent years, flavonoids have gained importance in the pharmaceutical field through their beneficial effects on human health and are widely available as nutritional supplements. Several pharmacological activities of the bioflavonoids may be useful in the prevention or treatment of ocular diseases responsible for vision loss such as diabetic retinopathy, macular degeneration, and cataract. This review summarizes potential therapeutic applications of various bioflavonoids in different ocular diseases and also discusses delivery of these agents to the ocular tissues. It is apparent that the flavonoids are capable of acting on various mecha- nisms or aetiological factors responsible for the development of different sight threatening ocular diseases. From a drug delivery perspective, ocular bioavailability depends on the physicochemical and biopharmaceutical characteristics of the selected flavonoids and very importantly the route of administration. The potential therapeutic applications of various bioflavonoids in ocular dis- eases is reviewed and the delivery of these agents to the ocular tissues is discussed. Whereas oral administration of bioflavonoids may demonstrate some pharmacological activity in the outer sections of the posterior ocular segment, protection of the retinal ganglionic cells in vivo may be limited by this delivery route. Systemic or local administration of these agents may yield much higher and effective concentrations of the parent bioflavonoids in the ocular tissues and at much lower doses.
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