Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.
Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.
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DOI：
10.1080/02772248.2011.586114
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发表时间：
2011
影响因子：
1.8
通讯作者：
Dietert RR
中科院分区：
文献类型：
--
作者：
Leifer CA;Dietert RR
先天免疫系统的组成部分，如巨噬细胞和树突状细胞，在决定免疫反应的命运中起着重要作用，也是早期生活环境改变（包括发育性免疫毒性（DIT））最敏感的目标之一。DIT可以阻碍先天免疫细胞成熟，破坏组织微环境，改变对感染挑战的免疫反应，并破坏调节反应。炎症的失调，例如在DIT中观察到的，与儿童和成人慢性炎症性疾病的风险增加有关。在这篇综述中，我们讨论了先天免疫调节和促进与慢性炎症疾病相关的炎症失调的早期生活危险因素之间的关系。dit相关炎症的健康风险可能超出原发性免疫功能障碍，包括晚年几种炎症介导的疾病的风险升高，这些疾病针对广泛的生理系统和器官。因此，确定先天免疫状态应该是药物和化学品安全性评价的一个组成部分。
Components of the innate immune system such as macrophages and dendritic cells are instrumental in determining the fate of immune responses and are, also, among the most sensitive targets of early life environmental alterations including developmental immunotoxicity (DIT). DIT can impede innate immune cell maturation, disrupt tissue microenvironment, alter immune responses to infectious challenges, and disrupt regulatory responses. Dysregulation of inflammation, such as that observed with DIT, has been linked with an increased risk of chronic inflammatory diseases in both children and adults. In this review, we discuss the relationship between early-life risk factors for innate immune modulation and promotion of dysregulated inflammation associated with chronic inflammatory disease. The health risks from DIT-associated inflammation may extend beyond primary immune dysfunction to include an elevated risk of several later-life, inflammatory-mediated diseases that target a wide range of physiological systems and organs. For this reason, determination of innate immune status should be an integral part of drug and chemical safety evaluation.
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DOI：
10.1080/15287390152543708
发表时间：
2001-10-12
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
影响因子：
--
作者：
Bunn, TL;Parsons, PJ;Dietert, RR
通讯作者：
Dietert, RR
影响因子：
4.4
作者：
Ahola, Aila J.;Thorn, Lena M.;Groop, Per-Henrik
通讯作者：
Groop, Per-Henrik
影响因子：
5.6
作者：
Bishayi, B;Sengupta, M
通讯作者：
Sengupta, M
影响因子：
1.5
作者：
Calderon-Garciduenas, Lilian;Macias-Parra, Mercedes;Maronpot, Robert R.
通讯作者：
Maronpot, Robert R.
影响因子：
24.3
作者：
Blacquiere, M. J.;Timens, W.;Hylkema, M. N.
通讯作者：
Hylkema, M. N.