Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
复制标题
脑缺血时长期给予选择性腺苷 A1 受体激动剂或拮抗剂。
DOI：
10.1016/0014-2999(94)90241-0
复制
发表时间：
1994
影响因子：
5
通讯作者：
Jacobson,KA
中科院分区：
文献类型：
--
作者：
VonLubitz,DK;Lin,RC;Melman,N;Ji,XD;Carter,MF;Jacobson,KA
The effect of chronic administration of selective adenosine A1receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown. Therefore, we have investigated the impact of such regimens on the hippocampal adenosine A1receptor density, and on the recovery from 10 min forebrain ischemia in gerbils. While acutely administeredN6-cyclopentyl-adenosine (CPA) given at 0.02 mg/kg resulted only in a significant reduction of mortality, at 1 mg/kg it improved both survival and neuronal preservation in the hippocampal CA1 region. Acute treatment with 1,3-dipropyl-8-cyclopentylxanthine (CPX) significantly worsened the outcome and enhanced neuronal destruction. The effects of chronic administration of these drugs (15 days followed by 1 drug-free day) were opposite. Thus, although chronic CPA at 0.02 mg/kg did not have any effect at all, at 1 mg/kg both survival and neuronal preservation were significantly poorer than in controls, while chronic CPX resulted in a significant improvement of both measures. These results were not accompanied by adenosine A1receptor up- or downregulation. Our study indicates that highly selective adenosine analogues may have therapeutic potential in treatment of cerebral ischemia/stroke and possibly other neurodegenerative disorders as well.
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DOI：
10.1002/neu.480230915
发表时间：
1992-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
CHOI, DW
通讯作者：
CHOI, DW
大脑的自卫：神经变性中的腺苷能策略
DOI：
--
发表时间：
1992
期刊：
影响因子：
--
作者：
K. Dag;E. Lubitz;P. Marangos
通讯作者：
P. Marangos
腺苷受体激活在缺血性脑损伤中的治疗潜力。
影响因子：
4.2
作者：
L. Miller;Chung Hsu
通讯作者：
Chung Hsu
影响因子：
2.1
作者：
J. Phillis;G. Kostopoulos;J. Limacher
通讯作者：
J. Limacher
环己基腺苷对沙鼠脑缺血的保护作用
影响因子：
3.3
作者：
D. V. Lubitz;J. Dambrosia;D. J. Edmond
通讯作者：
D. J. Edmond