Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector.
Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector.
复制标题
DOI：
10.1364/ol.34.000953
复制
发表时间：
2009-04-01
期刊：
影响因子：
3.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Wu Y;Xi J;Cobb MJ;Li X
研制了一种采用微型复合透镜和多模光纤集热器的柔性扫描光纤内镜，用于双光子荧光（TPF）和二次谐波（SHG）成像。复合透镜由一对非球面透镜组成，与梯度折射率透镜相比，具有较低的色差，从而提高了TPF/SHG的收集效率。在内镜显微镜双包层纤维远端引入短MMF收集器，进一步减轻了透镜色差的不利影响，提高了TPF/SHG收集效率。荧光珠的TPF成像和尾尾肌腱的SHG成像的射线追踪模拟和实验表明，采用复合透镜和MMF收集器的新型内镜设计，TPF （SHG）的收集效率提高了约9倍（约4倍）。
A flexible scanning fiber-optic endomicroscope using a miniature compound lens and a multimode-fiber (MMF) collector was developed for two-photon fluorescence (TPF) and second-harmonic generation (SHG) imaging. The compound lens consisted of a pair of aspherical lenses and exhibited reduced chromatic aberration compared with gradient-index lenses, thus increasing the TPF/SHG collection efficiency. The introduction of a short MMF collector at the distal end of the double-clad fiber of the endomicroscope further mitigated the adverse influence of chromatic aberration of the lens and enhanced the TPF/SHG collection efficiency. Both ray-tracing simulations and experiments on TPF imaging of fluorescent beads and SHG imaging of rattail tendon demonstrated approximately nine (approximately four) times improved collection efficiency for TPF (SHG) with the new endomicroscope design that utilized a compound lens and an MMF collector.
登录
查看更多内容
影响因子：
3.6
作者：
Liu, XM;Cobb, MJ;Li, XD
通讯作者：
Li, XD
影响因子：
3.6
作者：
Flusberg, BA;Lung, JC;Schnitzer, MJ
通讯作者：
Schnitzer, MJ
影响因子：
16.2
作者：
Helmchen, F;Fee, MS;Denk, W
通讯作者：
Denk, W
影响因子：
3.4
作者：
Campagnola, PJ;Millard, AC;Mohler, WA
通讯作者：
Mohler, WA
影响因子：
3.8
作者：
Fu, L;Jain, A;Gu, M
通讯作者：
Gu, M