Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring.
Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring.
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DOI：
10.1210/en.2016-1314
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发表时间：
2016-11
期刊：
影响因子：
4.8
通讯作者：
Ozanne SE
中科院分区：
文献类型：
--
作者：
Alfaradhi MZ;Kusinski LC;Fernandez-Twinn DS;Pantaleão LC;Carr SK;Ferland-McCollough D;Yeo GS;Bushell M;Ozanne SE
怀孕期间的肥胖对后代的健康有长期影响，包括患代谢综合征的风险。使用母体饮食诱导肥胖的小鼠模型，我们采用全基因组方法研究脂肪组织中的microRNA（miRNA）和miRNA转录谱，以了解发生这种情况的机制。饮食诱导的肥胖母亲的雄性后代，从断奶开始喂食对照饮食，在8周龄时体重或肥胖没有差异。然而，肥胖母鼠的后代脂肪组织中细胞因子（Tnfα; P <0.05）和趋化因子（Ccl 2和Ccl 7; P <0.05）信号传导上调。这伴随着miR-706的表达减少，我们发现miR-706可以直接调节炎性蛋白IL-33（上调41%; P <0.05）和钙/钙调蛋白依赖性蛋白激酶1D（上调30%; P <0.01）的翻译。我们的结论是，暴露于肥胖在发展过程中引发的炎症环境中的脂肪组织是独立的后代肥胖。调节炎症信号分子表达的脂肪组织miRNAs的编程可能是一种起作用的机制。
Obesity during pregnancy has a long-term effect on the health of the offspring including risk of developing the metabolic syndrome. Using a mouse model of maternal diet-induced obesity, we employed a genome-wide approach to investigate the microRNA (miRNA) and miRNA transcription profile in adipose tissue to understand mechanisms through which this occurs. Male offspring of diet-induced obese mothers, fed a control diet from weaning, showed no differences in body weight or adiposity at 8 weeks of age. However, offspring from the obese dams had up-regulated cytokine (Tnfα; P < .05) and chemokine (Ccl2 and Ccl7; P < .05) signaling in their adipose tissue. This was accompanied by reduced expression of miR-706, which we showed can directly regulate translation of the inflammatory proteins IL-33 (41% up-regulated; P < .05) and calcium/calmodulin-dependent protein kinase 1D (30% up-regulated; P < .01). We conclude that exposure to obesity during development primes an inflammatory environment in adipose tissue that is independent of offspring adiposity. Programming of adipose tissue miRNAs that regulate expression of inflammatory signaling molecules may be a contributing mechanism.
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影响因子：
3.7
作者：
Haney S;Zhao J;Tiwari S;Eng K;Guey LT;Tien E
通讯作者：
Tien E
影响因子：
8.1
作者：
Fernandez-Twinn DS;Alfaradhi MZ;Martin-Gronert MS;Duque-Guimaraes DE;Piekarz A;Ferland-McCollough D;Bushell M;Ozanne SE
通讯作者：
Ozanne SE
DOI：
10.1152/ajpregu.00049.2014
发表时间：
2014-07-01
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Alfaradhi MZ;Fernandez-Twinn DS;Martin-Gronert MS;Musial B;Fowden A;Ozanne SE
通讯作者：
Ozanne SE
影响因子：
4.8
作者：
LOETSCHER, P;SEITZ, M;MOSER, B
通讯作者：
MOSER, B
影响因子：
5.5
作者：
Proost, P;Wuyts, A;VanDamme, J
通讯作者：
VanDamme, J