Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.
Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.
复制标题
DOI：
10.1016/j.psychres.2017.10.047
复制
发表时间：
2018-01
影响因子：
11.3
通讯作者：
de Wit H
中科院分区：
文献类型：
--
作者：
Gray JC;MacKillop J;Weafer J;Hernandez KM;Gao J;Palmer AA;de Wit H
冲动性人格特征是成瘾和其他涉及去抑制的精神疾病的遗传危险因素和假定的内表型。本研究以Barratt冲动性量表（BIS-11）和UPPS-P冲动性行为量表（UPPS-P）的得分为依据，考察了冲动性人格特征的遗传基础。在983名具有欧洲血统的健康年轻人中，该研究基于高表型相互关系，检查了与七个亚量表组合表型相关的遗传变异。该研究首先测试了14个先验基因座，这些基因座先前与冲动性格特征或密切相关的结构有关。其次，该研究包括探索性全基因组扫描（即GWAS），承认在约1000个样本量中只能检测到相对较大的影响。先验SNP分析显示，组合冲动性表型与5-HT2a受体基因（HTR2A； rs6313和rs6311）中的两个SNP之间存在显著关联。随访分析表明，该效应仅存在于BIS-11的运动和非计划分量表中，且这两个基因座处于连锁不平衡状态。GWAS没有统计上显著的发现。这项研究进一步暗示了HTR2A内的基因座与某些形式的自我报告冲动有关，并从全基因组分析中确定了未来研究的候选基因。
Impulsive personality traits are heritable risk factors and putative endophenotypes for addiction and other psychiatric disorders involving disinhibition. This study examined the genetic basis of impulsive personality traits, defined as scores on the Barratt Impulsiveness Scale (BIS-11) and the UPPS-P Impulsive Behavior Scale (UPPS-P). In 983 healthy young adults of European ancestry, the study examined genetic variation in relation to a combined phenotype of seven subscales based on high phenotypic intercorrelations. The study first tested 14 a priori loci that have previously been associated impulsive personality traits or closely related constructs. Second, the study included an exploratory genome-wide scan (i.e., GWAS), acknowledging that only relatively large effects would be detectable in a sample size of ~1000. A priori SNP analyses revealed a significant association between the combined impulsivity phenotype and two SNPs within the 5-HT2a receptor gene (HTR2A; rs6313 and rs6311). Follow-up analyses suggested that the effects were specific to the Motor and Non-planning subscales on the BIS-11, and also that the two loci were in linkage disequilibrium. The GWAS yielded no statistically significant findings. This study further implicates loci within HTR2A with certain forms of self-reported impulsivity and identifies candidates for future investigation from the genome-wide analyses.
登录
查看更多内容
DOI：
10.1111/add.13535
发表时间：
2017-01
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Amlung M;Vedelago L;Acker J;Balodis I;MacKillop J
通讯作者：
MacKillop J
影响因子：
3.7
作者：
Eisenberg DT;Campbell B;Mackillop J;Lum JK;Wilson DS
通讯作者：
Wilson DS
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
10.6
作者：
Ersche, Karen D.;Turton, Abigail J.;Pradhan, Shachi;Bullmore, Edward T.;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
0.9
作者：
Dick, Danielle M.;Aliev, Fazil;Latendresse, Shawn;Porjesz, Bernice;Schuckit, Marc;Rangaswamy, Madhavi;Hesselbrock, Victor;Edenberg, Howard;Nurnberger, John, Jr.;Agrawal, Arpana;Bierut, Laura;Wang, Jen;Bucholz, Kathy;Kuperman, Samuel;Kramer, John
通讯作者：
Kramer, John