Differential effects of aging and sex on stroke induced inflammation across the lifespan.
Differential effects of aging and sex on stroke induced inflammation across the lifespan.
复制标题
DOI：
10.1016/j.expneurol.2013.08.011
复制
发表时间：
2013-11
影响因子：
5.3
通讯作者：
McCullough, Louise D.
中科院分区：
文献类型：
--
作者：
Manwani, Bharti;Liu, Fudong;Scranton, Victoria;Hammond, Matthew D.;Sansing, Lauren H.;McCullough, Louise D.
衰老和生物性别是中风结果的关键决定因素。缺血后炎症反应对缺血性脑损伤的程度有很大影响，但这种反应如何随年龄和性别变化尚不清楚。我们对年轻（5-6 个月）、中年（14-15 个月）和老年（20-22 个月）C57BL/6 雄性和雌性小鼠进行短暂大脑中动脉闭塞（MCAO），发现性别交互作用的年龄显着影响组织学卒中结果。随着年龄的增长，急性功能结果会更差。 MCAO 后大脑中的中性粒细胞、炎性巨噬细胞、巨噬细胞、树突状细胞 (DC) 和小胶质细胞显着增加。骑自行车的女性中风后大脑中的 Gr1− 非炎症巨噬细胞较高，T 细胞较低，这些与血清雌二醇水平相关。无环老年雌性小鼠雌激素的丧失加剧了中风引起的脾收缩。高龄损伤部位的 T 细胞、树突状细胞和小胶质细胞增多，这可能是老年人行为缺陷加剧的原因。我们得出的结论是，衰老和性别对中风后炎症环境有不同的影响。假定的免疫调节疗法需要考虑这种异质性。
Aging and biological sex are critical determinants of stroke outcome. Post-ischemic inflammatory response strongly contributes to the extent of ischemic brain injury, but how this response changes with age and sex is unknown. We subjected young (5–6 months), middle aged (14–15 months) and aged (20–22 months), C57BL/6 male and female mice to transient middle cerebral artery occlusion (MCAO) and found that a significant age by sex interaction influenced histological stroke outcomes. Acute functional outcomes were worse with aging. Neutrophils, inflammatory macrophages, macrophages, dendritic cells (DCs) and microglia significantly increased in the brain post MCAO. Cycling females had higher Gr1− non-inflammatory macrophages and lower T cells in the brain after stroke and these correlated with serum estradiol levels. Estrogen loss in acyclic aged female mice exacerbated stroke induced splenic contraction. Advanced age increased T cells, DCs and microglia at the site of injury, which may be responsible for the exacerbated behavioral deficits in the aged. We conclude that aging and sex have differential effects on the post stroke inflammatory milieu. Putative immunomodulatory therapies need to account for this heterogeneity.
登录
查看更多内容
LY6C+“炎症单核细胞”是在西尼罗河病毒脑炎中以致病方式募集的小胶质前体。
DOI：
10.1084/jem.20080421
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Getts DR;Terry RL;Getts MT;Müller M;Rana S;Shrestha B;Radford J;Van Rooijen N;Campbell IL;King NJ
通讯作者：
King NJ
影响因子：
4.4
作者：
Agrawal A;Sridharan A;Prakash S;Agrawal H
通讯作者：
Agrawal H
影响因子：
3.6
作者：
FELICIO, LS;NELSON, JF;FINCH, CE
通讯作者：
FINCH, CE
影响因子：
6.3
作者：
Denes, Adam;Vidyasagar, Rishma;Allan, Stuart M.
通讯作者：
Allan, Stuart M.
影响因子：
8.3
作者：
Gelderblom, Mathias;Leypoldt, Frank;Magnus, Tim
通讯作者：
Magnus, Tim