Pharmacokinetic Analysis of Enhancement-Constrained Acceleration (ECA) reconstruction-based high temporal resolution breast DCE-MRI.
Pharmacokinetic Analysis of Enhancement-Constrained Acceleration (ECA) reconstruction-based high temporal resolution breast DCE-MRI.
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DOI：
10.1371/journal.pone.0286123
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
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动态对比增强磁共振成像（DCE-MRI）的高空间和时间分辨率可以提高乳腺致密或乳腺癌高危患者乳腺癌筛查的诊断准确性。然而，DCE-MRI 的时空分辨率在临床实践中受到技术问题的限制。我们早期的工作演示了使用图像重建和增强约束加速（ECA）来提高时间分辨率。 ECA 利用连续图像采集之间的 k 空间相关性。由于这种相关性，并且由于注射造影剂后早期的增强非常稀疏，我们可以从高度欠采样的 k 空间数据重建图像。我们之前的结果表明，当 k 空间数据按照具有足够信噪比 (SNR) 的笛卡尔采样轨迹进行采样时，每幅图像 0.25 秒 (4 Hz) 的 ECA 重建可以比标准快速傅里叶逆变换 (IFFT) 更准确地估计推注到达时间 (BAT) 和初始增强斜率 (iSlope)。在这项后续研究中，我们研究了基于不同笛卡尔的采样轨迹、SNR 和加速度对 ECA 重建在评估病变（BAT、iSlope 和 Ktrans）和动脉中造影剂动力学（首次通过的峰值信号强度、到达峰值时间和 BAT）中的性能的影响。我们通过流模型实验进一步验证了 ECA 重建。我们的结果表明，通过“重复前进阶段欠采样”(UnWRAP) 轨迹采集的 k 空间数据的 ECA 重建，加速因子为 14，时间分辨率为 0.5 s/图像，高 SNR（SNR ≥ 30 dB，噪声标准差 (std) < 3%）可确保病变动力学中的较小误差（5% 或 1 s 误差）。需要中等 SNR（SNR ≥ 20 dB，噪声标准 ≤ 10%）才能准确测量动脉增强动力学。我们的结果还表明，使用 ECA 加速时间分辨率（0.5 秒/图像）是可行的。
The high spatial and temporal resolution of dynamic contrast-enhanced MRI (DCE-MRI) can improve the diagnostic accuracy of breast cancer screening in patients who have dense breasts or are at high risk of breast cancer. However, the spatiotemporal resolution of DCE-MRI is limited by technical issues in clinical practice. Our earlier work demonstrated the use of image reconstruction with enhancement-constrained acceleration (ECA) to increase temporal resolution. ECA exploits the correlation in k-space between successive image acquisitions. Because of this correlation, and due to the very sparse enhancement at early times after contrast media injection, we can reconstruct images from highly under-sampled k-space data. Our previous results showed that ECA reconstruction at 0.25 seconds per image (4 Hz) can estimate bolus arrival time (BAT) and initial enhancement slope (iSlope) more accurately than a standard inverse fast Fourier transform (IFFT) when k-space data is sampled following a Cartesian based sampling trajectory with adequate signal-to-noise ratio (SNR). In this follow-up study, we investigated the effect of different Cartesian based sampling trajectories, SNRs and acceleration rates on the performance of ECA reconstruction in estimating contrast media kinetics in lesions (BAT, iSlope and Ktrans) and in arteries (Peak signal intensity of first pass, time to peak, and BAT). We further validated ECA reconstruction with a flow phantom experiment. Our results show that ECA reconstruction of k-space data acquired with ‘Under-sampling with Repeated Advancing Phase’ (UnWRAP) trajectories with an acceleration factor of 14, and temporal resolution of 0.5 s/image and high SNR (SNR ≥ 30 dB, noise standard deviation (std) < 3%) ensures minor errors (5% or 1 s error) in lesion kinetics. Medium SNR (SNR ≥ 20 dB, noise std ≤ 10%) was needed to accurately measure arterial enhancement kinetics. Our results also suggest that accelerated temporal resolution with ECA with 0.5 s/image is practical.
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影响因子：
4.4
作者：
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