Serum CA 19-9 and risk of incident diabetes in middle-aged and elderly Chinese: a prospective cohort study
Serum CA 19-9 and risk of incident diabetes in middle-aged and elderly Chinese: a prospective cohort study
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中国中老年人血清CA 19-9与糖尿病发生风险：一项前瞻性队列研究
DOI：
10.1007/s00592-016-0937-y
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发表时间：
2017-02
影响因子：
3.8
通讯作者：
Lu Jieli
中科院分区：
文献类型：
--
作者：
Du Rui;Sun Wanwan;Lin Lin;Sun Jichao;Peng Kui;Xu Yu;Xu Min;Chen Yuhong;Bi Yufang;Wang Weiqing;Li Donghui;Lu Jieli
AimsCarbohydrate抗原（CA） 19-9是胃肠道和胰腺癌的肿瘤标志物。以往的研究发现CA 19-9在糖尿病患者中升高，但在前瞻性研究中对其与糖尿病风险的关系知之甚少。我们的目的是评估血清CA 19-9与中国人群发生糖尿病风险之间的关系。方法数据来自一项前瞻性队列研究，共纳入2391名中国中老年患者，中位随访3.8年。研究结果的测量是糖尿病发生率。结果与最低四分位数个体相比，CA 19-9最高四分位数个体的糖尿病发病率显著高于最低四分位数个体（12.54比8.86%，P= 0.04）。在完全调整后的logistic回归模型中，与最低四分位数相比，CA 19-9的最高四分位数与糖尿病发生风险增加58%显著相关[优势比（OR）， 95%可信区间（CI） 1.58, 1.02-2.44]。分层分析表明，风险增加仅发生在女性（OR, 95% CI 1.96, 1.10-3.48）、年龄≥65岁（OR, 95% CI 2.32, 1.03-5.19）、体重指数≥24 （OR, 95% CI 2.09, 1.20-3.63）、目前不饮酒者（OR, 95% CI 1.79, 1.09-2.92）、葡萄糖调节功能受损者（OR, 95% CI 2.49, 1.33-4.67）。IGR与血清CA 19-9之间存在显著交互作用（交互作用p <0.0001）。结论中国中老年人群血清CA 19-9与糖尿病发病风险显著增高相关。需要进一步的调查来证实这种关联并揭示潜在的机制。
AimsCarbohydrate antigen (CA) 19-9 is a tumor marker for gastrointestinal and pancreatic cancers. Previous studies found that CA 19-9 was elevated in patients with diabetes, but little is known about its relationship with diabetes risk in prospective studies. Our objective was to evaluate the association between serum CA 19-9 and the risk of incident diabetes in Chinese population.MethodsData were obtained from a prospective cohort study among 2391 middle-aged and elderly Chinese with a median follow-up of 3.8 years. The measurement for the study outcome was incident diabetes.ResultsCompared with individuals in the lowest quartile, those in the highest quartile of CA 19-9 had significantly higher incidence of diabetes (12.54 vs. 8.86%,P= 0.04). In the fully adjusted logistic regression model, compared with the lowest quartile, the highest quartile of CA 19-9 was significantly associated with 58% increased risk of incident diabetes [odds ratio (OR), 95% confidence interval (CI) 1.58, 1.02–2.44]. Stratified analysis suggested that the increased risk was seen only in women (OR, 95% CI 1.96, 1.10–3.48), or participants aged ≥65 (OR, 95% CI 2.32, 1.03–5.19), or those with body mass index ≥24 (OR, 95% CI 2.09, 1.20–3.63), or current nondrinkers (OR, 95% CI 1.79, 1.09–2.92), or those with impaired glucose regulation (IGR) (OR, 95% CI 2.49, 1.33–4.67). Significant interaction was detected between IGR and serum CA 19-9 (Pfor interaction <0.0001).ConclusionsSerum CA 19-9 is associated with a significantly increased risk of diabetes among the middle-aged and elderly Chinese population. Further investigations are needed to confirm this association and disclose potential mechanisms.
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影响因子：
16.2
作者：
Wang T;Lu J;Xu Y;Li M;Sun J;Zhang J;Xu B;Xu M;Chen Y;Bi Y;Wang W;Ning G
通讯作者：
Ning G
影响因子：
3.1
作者：
Gul, Kamile;Nas, Sevinc;Cakir, Bekir
通讯作者：
Cakir, Bekir
影响因子：
16.2
作者：
Effoe VS;Correa A;Chen H;Lacy ME;Bertoni AG
通讯作者：
Bertoni AG
影响因子：
11.2
作者：
J. Magnani;Z. Steplewski;H. Koprowski;V. Ginsburg
通讯作者：
J. Magnani;Z. Steplewski;H. Koprowski;V. Ginsburg
影响因子：
4.3
作者：
Uygur-Bayramicli, Oya;Dabak, Resat;Mayadagli, Alpaslan
通讯作者：
Mayadagli, Alpaslan