Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.

Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.
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DOI:
10.1002/anie.201305510
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发表时间:
2013-09-16
影响因子:
16.6
通讯作者:
Lawrence, David S.
Lawrence, David S.
中科院分区:
化学1区
文献类型:
--
作者:
Nguyen, Luong T.;Oien, Nathan P.;Allbritton, Nancy L.;Lawrence, David S.

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Lipidated light-responsive constructs that sequester bioagents to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.
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