Change in Lumbar Muscle Size and Composition on MRI with Long-Duration Spaceflight.
Change in Lumbar Muscle Size and Composition on MRI with Long-Duration Spaceflight.
复制标题
长时间航天飞行时腰部肌肉大小和成分的MRI改变。
DOI：
10.1007/s10439-022-02968-3
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发表时间：
2022-07
影响因子：
3.8
通讯作者：
Weaver, Ashley A.
中科院分区：
文献类型：
--
作者：
Greene, Katelyn A.;Tooze, Janet A.;Lenchik, Leon;Weaver, Ashley A.
关键词：
长时间的微重力会导致肌肉萎缩，特别是抗重力脊髓肌肉。个体椎旁肌群的大小和组成如何随着航天飞行而变化需要进一步探索。本研究采用磁共振成像（MRI）无创测量肌肉变化的方法，调查了6名长期太空任务宇航员的腰椎肌肉组织变化。使用混合模型分析飞行前和飞行后腰椎图像的腰大肌（PS）、腰方肌（QL）和椎旁[竖脊肌和多裂肌（ES + MF）]的横截面积、体积和脂肪浸润的变化。机组人员使用船上的运动设备，包括自行车测力计（CEVIS），跑步机（T2/COLBERT）和先进的阻力运动设备（ARED）。相关性用于评估与运动方式相关的肌肉变化。机组人员的肌肉变化存在很大差异，但总体上椎旁面积显著减少（-9.0 ± 4.8%，p = 0.04），QL脂肪浸润显著增加（7.3 ± 4.1%，p = 0.05）。更多的CEVIS时间可以防止PS体积损失（p = 0.05）和PS脂肪浸润（p < 0.01），更多的ARED使用可以防止ES + MF体积损失（p = 0.05）。使用现代机载运动设备的船员可能不太容易受到肌肉变化的影响。然而，机组人员之间的差异以及肌肉大小和质量的损失表明，需要进行更多的研究，以确保飞行中的对策保护肌肉健康。
Prolonged microgravity results in muscle atrophy, especially among the anti-gravity spinal muscles. How individual paravertebral muscle groups change in size and composition with spaceflight needs further exploration. This study investigates lumbar spine musculature changes among six crewmembers on long-duration space missions using noninvasive measurement of muscle changes with magnetic resonance imaging (MRI). Pre- and post-flight lumbar images were analyzed for changes in cross-sectional area, volume, and fat infiltration of the psoas (PS), quadratus lumborum (QL), and paraspinal [erector spinae and multifidus (ES + MF)] muscles using mixed models. Crewmembers used onboard exercise equipment, including a cycle ergometer (CEVIS), treadmill (T2/COLBERT), and the advanced resistive exercise device (ARED). Correlations were used to assess muscle changes related to exercise modality. There was substantial variability in muscle changes across crewmembers but collectively a significant decrease in paraspinal area (− 9.0 ± 4.8%, p = 0.04) and a significant increase in QL fat infiltration (7.3 ± 4.1%, p = 0.05). More CEVIS time may have protected against PS volume loss (p = 0.05) and PS fat infiltration (p < 0.01), and more ARED usage may have protected against ES + MF volume loss (p = 0.05). Crewmembers using modern onboard exercise equipment may be less susceptible to muscle changes. However, variability between crewmembers and muscle size and quality losses suggest additional research is needed to ensure in-flight countermeasures preserve muscle health.
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DOI：
10.1359/jbmr.090807
发表时间：
2010-03
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Lang T;Cauley JA;Tylavsky F;Bauer D;Cummings S;Harris TB;Health ABC Study
通讯作者：
Health ABC Study
影响因子：
3
作者：
Burkhart, Katelyn;Allaire, Brett;Bouxsein, Mary L.
通讯作者：
Bouxsein, Mary L.
影响因子：
2.8
作者：
Ranson, Craig A.;Burnett, Angus F.;O'Sullivan, Peter B.
通讯作者：
O'Sullivan, Peter B.
影响因子：
3.8
作者：
Greene KA;Withers SS;Lenchik L;Tooze JA;Weaver AA
通讯作者：
Weaver AA
影响因子：
2.3
作者：
Garcia, Kathleen M.;Harrison, Michael F.;Dulchavsky, Scott A.
通讯作者：
Dulchavsky, Scott A.