Medial Temporal Lobe Atrophy is Related to Learning Strategy Changes in Amnestic Mild Cognitive Impairment
Medial Temporal Lobe Atrophy is Related to Learning Strategy Changes in Amnestic Mild Cognitive Impairment
复制标题
内侧颞叶萎缩与遗忘型轻度认知障碍的学习策略变化有关
DOI：
10.1017/s1355617719000353
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发表时间：
2019-08
影响因子：
2.6
通讯作者：
Zhang Nan
中科院分区：
文献类型：
--
作者：
Zhang Liling;Sun Wen hao;Xing Mengya;Wang Yue;Zhang Yuanyuan;Sun Qingna;Cheng Yan;Shi Chuan;Zhang Nan
摘要目的：本研究观察了遗忘性轻度认知障碍（aMCI）患者语义学习策略的缺陷。在本研究中，我们探讨了执行功能和大脑结构变化对aMCI语义学习策略下降的贡献。方法：采用神经心理学电池测试96名aMCI受试者和90名年龄和性别匹配的健康对照（hc）的记忆和执行功能。计算语言学习测试的语义聚类率来评估学习策略。MRI上分别用MTA和Fazekas视觉评分量表测量内侧颞叶萎缩（MTA）和白质高信号（WMH）。结果：与hc相比，aMCI受试者在记忆、执行功能和语义聚类率方面的表现较差（P < 0.001）。在aMCI被试中，学习策略与执行功能之间没有显著的相关性。具有明显MTA的aMCI受试者的语义聚类比不具有MTA的aMCI受试者低（P < 0.001）。在学习策略方面，高、低度WMH被试在学习策略上无显著差异。结论：aMCI受试者在语义学习策略方面表现出明显的障碍，这种障碍与MTA有关，但与执行功能障碍和皮层下WMH无关。这些发现需要在使用脑容量测量确定的生物标志物的大型队列中进一步验证。（生物工程学报，2019,25,706-717）
Abstract Objective: Deficits in the semantic learning strategy were observed in subjects with amnestic mild cognitive impairment (aMCI) in our previous study. In the present study, we explored the contributions of executive function and brain structure changes to the decline in the semantic learning strategy in aMCI. Methods: A neuropsychological battery was used to test memory and executive function in 96 aMCI subjects and 90 age- and gender-matched healthy controls (HCs). The semantic clustering ratio on the verbal learning test was calculated to evaluate learning strategy. Medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) were measured on MRI with the MTA and Fazekas visual rating scales, respectively. Results: Compared to HCs, aMCI subjects had poorer performance in terms of memory, executive function, and the semantic clustering ratio (P < .001). In aMCI subjects, no significant correlation between learning strategy and executive function was observed. aMCI subjects with obvious MTA demonstrated a lower semantic clustering ratio than those without MTA (P < .001). There was no significant difference in the learning strategies between subjects with high-grade WMH and subjects with low-grade WMH. Conclusion: aMCI subjects showed obvious impairment in the semantic learning strategy, which was attributable to MTA but independent of executive dysfunction and subcortical WMH. These findings need to be further validated in large cohorts with biomarkers identified using volumetric brain measurements. (JINS, 2019, 25, 706–717)
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影响因子：
2.9
作者：
Naya, Yuji
通讯作者：
Naya, Yuji
影响因子：
4.4
作者：
DeCarli, C
通讯作者：
DeCarli, C
DOI：
10.1076/jcen.20.5.673.1119
发表时间：
1998-10
影响因子：
2.2
作者：
Helmut Hildebrandt;Andreas Brand;Wilfried Sachsenheimer
通讯作者：
Helmut Hildebrandt;Andreas Brand;Wilfried Sachsenheimer
DOI：
10.1097/00006199-197005000-00029
发表时间：
1969-09
期刊：
The Gerontologist
影响因子：
--
作者：
M. Lawton;E. Brody
通讯作者：
M. Lawton;E. Brody
影响因子：
3.2
作者：
Becker, S;Lim, J
通讯作者：
Lim, J